需要在大学环境中进行生殖器支原体大环内酯耐药性检测。

IF 1.2 Q2 MEDICINE, GENERAL & INTERNAL
Stephen C Lavey, Brittany Cassel, Erik Munson
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引用次数: 0

摘要

背景:生殖器支原体是一种难以控制的性传播感染(STI),因为它可能产生抗菌药耐药性和感染后遗症。大学生尤其容易受到感染,因为他们是美国性传播感染率最高的人群。因此,调查这一人群的感染率和治疗效果对于最大限度地减少生殖器疱疹的未来影响至关重要。 本研究旨在调查大学生群体中生殖器疱疹的分布情况和治疗效果:设计:对大学健康诊所就诊者进行回顾性图表审查,并在治疗干预后对 M. genitalium 进行实验室检测:从 2017 年 11 月到 2020 年 2 月的 28 个月期间,美国中西部一所大学健康诊所共接待了 1617 名学生,分析了生殖器疱疹病毒和沙眼衣原体的阳性率和流行率。这些性传播病原体的检测是通过商业 RNA 扩增检测进行的。病历审查的重点是最初检测出生殖器疱疹病毒并进行治疗干预后的结果:结果:沙眼衣原体阳性率和流行率分别为 7.05% 和 9.00%,而 M. 生殖器茵的阳性率和流行率分别为 7.05% 和 6.51%。在任何时间感染 M. 生殖器桿菌的参与者平均产生 1.83 个阳性结果,而沙眼衣原体平均产生 1.17 个阳性结果(P < 0.0002)。在接受阿奇霉素治疗的学生中,30.3%的学生在随访时M. 生殖器畸形结果为阴性,每天1克和2天500毫克剂量方案的疗效低于4天250毫克剂量方案或莫西沙星:数据表明,有必要在大学环境中对原始标本进行大环内酯类药物耐药性分子测定。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mycoplasmoides genitalium Macrolide Resistance Detection is Needed in University Settings.

Background: Mycoplasmoides genitalium remains a difficult sexually-transmitted infection (STI) to manage due to its potential for antimicrobial resistance and post-infection sequelae. University students are especially vulnerable, as this demographic has the highest rate of STI in the United States. As a result, investigating prevalence rates and therapeutic outcomes in this population is essential to minimize future impact of M. genitalium The purpose of this study was to investigate a university student population for M. genitalium distribution and treatment outcome.Design: Retrospective chart-review of university health clinic attendees, augmented by laboratory detection of M. genitalium following therapeutic intervention.Methods: A total of 1617 student encounters at a midwestern United States university health clinic over a 28-month interval from November 2017 through February 2020 were analyzed for M. genitalium and Chlamydia trachomatis positivity rates and prevalence. Detection of these sexually-transmitted pathogens occurred by commercial RNA amplification testing. Chart review was focused on participant outcomes following initial M. genitalium detection and therapeutic intervention.Results: C. trachomatis positivity and prevalence rates were 7.05% and 9.00%, respectively, while analogous rates for M. genitalium were 7.05% and 6.51%, respectively. An average of 1.83 positive results was generated from participants infected with M. genitalium at any time, with an average of 1.17 positive results for C. trachomatis (P < 0.0002). For students treated with azithromycin, 30.3% generated a negative M. genitalium result upon follow-up, with 1g daily and 2-day 500mg dosing regimens demonstrating less efficacy than a 4-day 250mg regimen or moxifloxacin.Conclusion: Data indicate a need for molecular M. genitalium macrolide resistance determination from primary specimens in the university setting.

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来源期刊
Clinical Medicine & Research
Clinical Medicine & Research MEDICINE, GENERAL & INTERNAL-
CiteScore
1.80
自引率
7.10%
发文量
25
期刊介绍: Clinical Medicine & Research is a peer reviewed publication of original scientific medical research that is relevant to a broad audience of medical researchers and healthcare professionals. Articles are published quarterly in the following topics: -Medicine -Clinical Research -Evidence-based Medicine -Preventive Medicine -Translational Medicine -Rural Health -Case Reports -Epidemiology -Basic science -History of Medicine -The Art of Medicine -Non-Clinical Aspects of Medicine & Science
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