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化学伴侣在蛋白质折叠之外的新陈代谢中的作用

IF 11.4 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Trends in Endocrinology and Metabolism Pub Date : 2024-07-01 Epub Date: 2024-04-24 DOI:10.1016/j.tem.2024.04.006
Ester Zito, Alain Lescure, Nica Borgese
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引用次数: 0

摘要

化学伴侣是一种能改善蛋白质折叠的小分子，可减轻因蛋白质折叠错误而导致的异常病理表型。最近的报道表明，化学伴侣在缓解内质网（ER）压力的同时，还能挽救线粒体功能和胰岛素信号传导。这些作用可能是化学伴侣对代谢要求高的组织产生药理作用的基础。
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Chemical chaperones in metabolic fitness beyond protein folding.

Chemical chaperones are small molecules that improve protein folding, alleviating aberrant pathological phenotypes due to protein misfolding. Recent reports suggest that, in parallel with their role in relieving endoplasmic reticulum (ER) stress, chemical chaperones rescue mitochondrial function and insulin signaling. These effects may underlie their pharmacological action on metabolically demanding tissues.

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来源期刊
Trends in Endocrinology and Metabolism
Trends in Endocrinology and Metabolism 医学-内分泌学与代谢
CiteScore
20.10
自引率
0.00%
发文量
98
审稿时长
82 days
期刊介绍： Trends in Endocrinology and Metabolism (TEM) stands as a premier Reviews journal in the realms of metabolism and endocrinology. Our commitment is reflected in the publication of refined, concise, and highly impactful articles that delve into cutting-edge topics, encompassing basic, translational, and clinical aspects. From state-of-the-art treatments for endocrine diseases to groundbreaking developments in molecular biology, TEM provides comprehensive coverage. Explore recent advancements in diabetes, endocrine diseases, obesity, neuroendocrinology, immunometabolism, molecular and cellular biology, and a myriad of other areas through our journal. TEM serves as an invaluable resource for researchers, clinicians, lecturers, teachers, and students. Each monthly issue is anchored by Reviews and Opinion articles, with Reviews meticulously chronicling recent and significant developments, often contributed by leading researchers in specific fields. Opinion articles foster debate and hypotheses. Our shorter pieces include Science & Society, shedding light on issues at the intersection of science, society, and policy; Spotlights, which focus on exciting recent developments in the literature, and single-point hypotheses as Forum articles. We wholeheartedly welcome and encourage responses to previously published TEM content in the form of Letters.
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