硒、糖尿病及其错综复杂的性别特异性关系。

IF 11.4 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Trends in Endocrinology and Metabolism Pub Date : 2024-09-01 Epub Date: 2024-04-10 DOI:10.1016/j.tem.2024.03.004

Kamil Demircan, Thilo Samson Chillon, Jeyoung Bang, Vadim N Gladyshev, Lutz Schomburg

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引用次数: 0

摘要

硒（Se）是一种人体必需的微量元素，在生物合成过程中以硒代半胱氨酸（Sec）的形式插入硒蛋白中，协调硒蛋白的表达和活性。硒对健康既有益处也有害处，供应不足或无节制地补充硒会引起人们的担忧。特别是，在一项随机对照试验（RCT）的二次分析中，Se 与 2 型糖尿病（T2D）发病率的增加有关。在本综述中，我们将讨论 Se 与糖尿病之间错综复杂的关系以及现有临床和实验研究的局限性。最近的证据表明，妊娠期糖尿病（GDM）存在性别二形性和 Se 缺乏相关性。我们强调了新出现的证据，即高 Se 状态与改善 T2D 患者预后和降低大血管并发症风险有关。

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Selenium, diabetes, and their intricate sex-specific relationship.

Selenium (Se) is an essential trace element, which is inserted as selenocysteine (Sec) into selenoproteins during biosynthesis, orchestrating their expression and activity. Se is associated with both beneficial and detrimental health effects; deficient supply or uncontrolled supplementation raises concerns. In particular, Se was associated with an increased incidence of type 2 diabetes (T2D) in a secondary analysis of a randomized controlled trial (RCT). In this review, we discuss the intricate relationship between Se and diabetes and the limitations of the available clinical and experimental studies. Recent evidence points to sexual dimorphism and an association of Se deficiency with gestational diabetes mellitus (GDM). We highlight the emerging evidence linking high Se status with improved prognosis in patients with T2D and lower risk of macrovascular complications.

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来源期刊

Trends in Endocrinology and Metabolism 医学-内分泌学与代谢

CiteScore

20.10

自引率

0.00%

发文量

审稿时长

82 days

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