卵母细胞发育过程中线粒体的形态、分布和活性。

IF 11.4 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Trends in Endocrinology and Metabolism Pub Date : 2024-10-01 Epub Date: 2024-04-09 DOI:10.1016/j.tem.2024.03.002
Devesh Bahety, Elvan Böke, Aida Rodríguez-Nuevo
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引用次数: 0

摘要

线粒体在细胞功能中起着至关重要的作用,并具有显著的可塑性,可调整其结构和活性,以满足细胞不断变化的能量需求。卵母细胞是成为卵子的雌性生殖细胞,它经历了独特的转变:休眠期延长,细胞体积大幅增大,随后成熟,涉及下一代遗传物质的分离,这些都带来了独特的新陈代谢挑战,需要线粒体做出不同的适应性调整。最近在休眠卵母细胞中的发现挑战了既有的呼吸复合体层次结构,并强调了长寿命卵母细胞中线粒体的可塑性程度。在这篇综述中,我们讨论了在三个脊椎动物物种(爪蟾、小鼠和人类)的卵母细胞发育过程中观察到的线粒体适应性,强调了当前的知识,承认了局限性,并概述了未来的研究方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mitochondrial morphology, distribution and activity during oocyte development.

Mitochondria have a crucial role in cellular function and exhibit remarkable plasticity, adjusting both their structure and activity to meet the changing energy demands of a cell. Oocytes, female germ cells that become eggs, undergo unique transformations: the extended dormancy period, followed by substantial increase in cell size and subsequent maturation involving the segregation of genetic material for the next generation, present distinct metabolic challenges necessitating varied mitochondrial adaptations. Recent findings in dormant oocytes challenged the established respiratory complex hierarchies and underscored the extent of mitochondrial plasticity in long-lived oocytes. In this review, we discuss mitochondrial adaptations observed during oocyte development across three vertebrate species (Xenopus, mouse, and human), emphasising current knowledge, acknowledging limitations, and outlining future research directions.

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来源期刊
Trends in Endocrinology and Metabolism
Trends in Endocrinology and Metabolism 医学-内分泌学与代谢
CiteScore
20.10
自引率
0.00%
发文量
98
审稿时长
82 days
期刊介绍: Trends in Endocrinology and Metabolism (TEM) stands as a premier Reviews journal in the realms of metabolism and endocrinology. Our commitment is reflected in the publication of refined, concise, and highly impactful articles that delve into cutting-edge topics, encompassing basic, translational, and clinical aspects. From state-of-the-art treatments for endocrine diseases to groundbreaking developments in molecular biology, TEM provides comprehensive coverage. Explore recent advancements in diabetes, endocrine diseases, obesity, neuroendocrinology, immunometabolism, molecular and cellular biology, and a myriad of other areas through our journal. TEM serves as an invaluable resource for researchers, clinicians, lecturers, teachers, and students. Each monthly issue is anchored by Reviews and Opinion articles, with Reviews meticulously chronicling recent and significant developments, often contributed by leading researchers in specific fields. Opinion articles foster debate and hypotheses. Our shorter pieces include Science & Society, shedding light on issues at the intersection of science, society, and policy; Spotlights, which focus on exciting recent developments in the literature, and single-point hypotheses as Forum articles. We wholeheartedly welcome and encourage responses to previously published TEM content in the form of Letters.
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