基于结构特征分析的肿瘤抑制因子 PDCD4 与疾病关系的研究进展。

Q3 Medicine

遗传 Pub Date : 2024-04-20 DOI:10.16288/j.yczz.23-291

Hui Li, Guang-Ming Wu

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引用次数: 0

摘要

肿瘤抑制因子程序性细胞死亡 4（PDCD4）在各种肿瘤组织中下调，表明预后不良。PDCD4 是第一个被发现通过抑制翻译来抵抗肿瘤转化、侵袭和转移的蛋白质。PDCD4 的功能取决于其结构，并受细胞外信号的影响。它通过多种机制调节肿瘤相关蛋白，特别是参与 PI3K-Akt-mTOR 和 MAPK 两大信号通路。本综述通过分析 PDCD4 的结构、功能和疾病之间的关系，总结了近年来 PDCD4 在细胞凋亡、自噬、肿瘤和炎症等多个生理过程和疾病中的作用，从而为研究 PDCD4 及相关蛋白的信号通路以及针对它们的疾病治疗提供启示。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Progress on the relationship between tumor suppressor PDCD4 and diseases based on the analysis of structural characteristics.

The tumor suppressor programmed cell death 4 (PDCD4) is downregulated in various tumor tissues indicating poor prognosis. PDCD4 is the first protein found to resist tumor transformation, invasion, and metastasis by inhibiting translation. The functions of PDCD4 dependent on its structures are affected by extracellular signals. It regulates tumor-related proteins through a variety of mechanisms, especially involved in two major signaling pathways, PI3K-Akt-mTOR and MAPK. By analyzing the relationship between the structures, functions and diseases of PDCD4, this review summarizes the roles of PDCD4 in several physiological processes and diseases such as apoptosis, autophagy, tumor, and inflammation in recent years, thereby providing insights for the study of the signaling pathways of PDCD4 and related proteins and the treatment of diseases targeting them.

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来源期刊

遗传 Medicine-Medicine (all)

CiteScore

2.50

自引率

0.00%

发文量

6699

期刊介绍： Hereditas is a national academic journal sponsored by the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences and the Chinese Society of Genetics and published by Science Press. It is a Chinese core journal and a Chinese high-quality scientific journal. The journal mainly publishes innovative research papers in the fields of genetics, genomics, cell biology, developmental biology, biological evolution, genetic engineering and biotechnology; new technologies and new methods; monographs and reviews on hot issues in the discipline; academic debates and discussions; experience in genetics teaching; introductions to famous geneticists at home and abroad; genetic counseling; information on academic conferences at home and abroad, etc. Main columns: review, frontier focus, research report, technology and method, resources and platform, experimental operation guide, genetic resources, genetics teaching, scientific news, etc.