自闭症谱系障碍中的小胶质细胞功能障碍

IF 3.5 3区医学 Q1 CLINICAL NEUROLOGY

Neuroscientist Pub Date : 2024-12-01 Epub Date: 2024-05-07 DOI:10.1177/10738584241252576

Jian Meng, Lingliang Zhang, Yun-Wu Zhang

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引用次数: 0

摘要

自闭症谱系障碍（ASD）是一种发病于儿童期的高度异质性神经发育障碍。自闭症谱系障碍的分子机制尚未完全阐明。已有证据表明，小胶质细胞功能障碍与 ASD 的病因之间存在联系。本综述总结了目前有关神经炎症和突触修剪中的小胶质细胞功能障碍的研究，这些障碍与 ASD 中转录组和自噬的改变有关。此外，还探讨了 ASD 中肠道微生物群的菌群失调及其与微神经胶质细胞功能障碍的相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Microglial Dysfunction in Autism Spectrum Disorder.

Autism spectrum disorder (ASD) is a highly heterogeneous neurodevelopmental disorder with onset in childhood. The molecular mechanisms underlying ASD have not yet been elucidated completely. Evidence has emerged to support a link between microglial dysfunction and the etiology of ASD. This review summarizes current research on microglial dysfunction in neuroinflammation and synaptic pruning, which are associated with altered transcriptomes and autophagy in ASD. Dysbiosis of gut microbiota in ASD and its correlation with microglial dysfunction are also addressed.

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来源期刊

Neuroscientist 医学-临床神经学

CiteScore

11.50

自引率

0.00%

发文量

期刊介绍： Edited by Stephen G. Waxman, The Neuroscientist (NRO) reviews and evaluates the noteworthy advances and key trends in molecular, cellular, developmental, behavioral systems, and cognitive neuroscience in a unique disease-relevant format. Aimed at basic neuroscientists, neurologists, neurosurgeons, and psychiatrists in research, academic, and clinical settings, The Neuroscientist reviews and updates the most important new and emerging basic and clinical neuroscience research.