评估大鼠模型玻璃体内氯胺酮给药对玻璃体视网膜组织的组织病理学结果和安全性：一项试验性研究。

IF 1.2 Q3 OPHTHALMOLOGY

Journal of Current Ophthalmology Pub Date : 2024-03-29 eCollection Date: 2023-07-01 DOI:10.4103/joco.joco_230_23

Mehdi Sanatkar, Zohreh Nozarian, Parisa Abdi, Fatemeh Bazvand

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引用次数: 0

摘要

目的：评估大鼠玻璃体内注射氯胺酮的安全性和组织学结果：方法：在无菌条件下全身麻醉，每只大鼠接受总量为0.1 ml的0.01 mol/L氯胺酮（5只大鼠为氯胺酮组）或总量为0.1 ml的0.9%生理盐水（5只大鼠为对照组）。玻璃体内注射 1 个月后进行组织学评估：结果：氯胺酮组和生理盐水组的 5 份标本均未出现晶状体混浊、视网膜层和视盘坏死和萎缩。两组样本的玻璃体、视网膜层、脉络膜、视盘和视神经均未出现炎症：结论：特殊剂量的氯胺酮玻璃体内注射对不同的眼内组织没有明显的不良影响。

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Evaluation of Histopathologic Findings and Safety of Intravitreal Ketamine Administration on Vitreoretinal Tissue in Rat Model: A Pilot Study.

Purpose: To evaluate the safety and histological findings of intravitreal injection of ketamine in rats.

Methods: Each rat received a total volume of 0.1 ml of ketamine 0.01 mol/L (5 rats as ketamine group) or a total of 0.1 ml of normal saline 0.9% (5 rats as control group) under general anesthesia in a sterile condition. A histology assessment was performed 1 month after the intravitreal injection.

Results: Lens opacity, necrosis, and atrophy of retinal layers and optic disc were not seen in five specimens in the ketamine group and five in the normal saline group. There was no inflammation in the vitreous, retinal layers, choroid, optic disc, and optic nerve in both groups.

Conclusion: Intravitreal injection of ketamine in a special dose has no obvious adverse effect on diverse intraocular tissue.

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来源期刊

Journal of Current Ophthalmology OPHTHALMOLOGY-

CiteScore

2.50

自引率

6.70%

发文量

审稿时长

8 weeks

期刊介绍： Peer Review under the responsibility of Iranian Society of Ophthalmology Journal of Current Ophthalmology, the official publication of the Iranian Society of Ophthalmology, is a peer-reviewed, open-access, scientific journal that welcomes high quality original articles related to vision science and all fields of ophthalmology. Journal of Current Ophthalmology is the continuum of Iranian Journal of Ophthalmology published since 1969.