肿瘤相关中性粒细胞对乳腺癌预后的影响

IF 1.1 Q4 ONCOLOGY
International journal of clinical and experimental pathology Pub Date : 2024-03-15 eCollection Date: 2024-01-01 DOI:10.62347/JQDQ1527
Akinari Kakumoto, Tsengelmaa Jamiyan, Hajime Kuroda, Oi Harada, Tomomi Yamaguchi-Isochi, Shogo Baba, Yasutaka Kato, Hiroshi Nishihara, Hiroyuki Kawami
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引用次数: 0

摘要

目的:中性粒细胞是哺乳动物中最常见的白细胞类型,在先天性免疫系统和抗癌反应中发挥着重要作用。然而,最近的研究发现,肿瘤相关中性粒细胞(TANs)的存在是一个不良预后因素。本研究探讨了TANs与乳腺癌的临床病理因素和遗传状态之间是否存在关系:方法:纳入北杜医院在2014年至2021年期间接受过充分活检、保乳手术或乳房切除术标本的196例乳腺癌患者:对肿瘤基质(TS)和瘤巢(TN)中的TANs进行了单独计数。TANs在TS和TN中的高密度与肿瘤大小(TS P = 0.010; TN P = 0.001)、组织学分级高(TS P < 0.001; TN P < 0.001)、组织学类型(TS P = 0.009; TN P = 0.034)、淋巴结转移比例高(TS P < 0.001; TN P < 0.001)、癌症晚期(TS P < 0.001; TN P = 0.002)、固有亚型(TS P < 0.001; TN P < 0.001)、ERBB2(TS P < 0.001; TN P < 0.001)、MAP3K1(TS P = 0.002; TN P = 0.023)和TP53(TS P < 0.001; TN P < 0.001)。TS和TN中较高密度的TAN也与较短的无病生存期和总生存期相关(P < 0.001):本研究结果表明,较高密度的TANs与乳腺癌的不利预后因素相关。需要进一步研究乳腺癌中与TANs相关的临床病理和遗传因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prognostic impact of tumor-associated neutrophils in breast cancer.

Objectives: Neutrophils are the most common type of leukocyte in mammals and play an essential role in the innate immune system and anti-cancer responses. However, recent studies identified the presence of tumor-associated neutrophils (TANs) as a poor prognostic factor. The present study investigated whether relationships exist between TANs and the clinicopathological factors and genetic status of breast cancer.

Methods: A total of 196 breast cancer patients with sufficient biopsy, breast-conserving surgery, or mastectomy specimens between 2014 and 2021 in Hokuto Hospital were included.

Results: TANs were individually counted in the tumor stroma (TS) and tumor nest (TN). A higher density of TANs in both TS and TN correlated with tumor size (TS P = 0.010; TN P = 0.001), a high histological grade (TS P < 0.001; TN P < 0.001), the histological type (TS P = 0.009; TN P = 0.034), a high ratio of lymph node metastasis (TS P < 0.001; TN P < 0.001), an advanced stage of cancer (TS P < 0.001; TN P = 0.002), intrinsic subtypes (TS P < 0.001; TN P < 0.001), ERBB2 (TS P < 0.001; TN P < 0.001), MAP3K1 (TS P = 0.002; TN P = 0.023), and TP53 (TS P < 0.001; TN P < 0.001). A higher density of TANs in TS and TN also correlated with shorter disease-free survival and overall survival (P < 0.001).

Conclusion: The present results suggest that a higher density of TANs correlates with unfavorable prognostic factors in breast cancer. Further research on clinicopathological and genetic factors associated with TANs in breast cancer is needed.

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来源期刊
自引率
0.00%
发文量
42
审稿时长
1 months
期刊介绍: The International Journal of Clinical and Experimental Pathology (IJCEP, ISSN 1936-2625) is a peer reviewed, open access online journal. It was founded in 2008 by an international group of academic pathologists and scientists who are devoted to the scientific exploration of human disease and the rapid dissemination of original data. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal.
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