{"title":"地氟醚麻醉期间双侧额叶脑电图的耦合特征与年龄有关。","authors":"Ziyang Li, Peiqi Wang, Licheng Han, Xinyu Hao, Weidong Mi, Li Tong, Zhenhu Liang","doi":"10.1088/1361-6579/ad46e0","DOIUrl":null,"url":null,"abstract":"<p><p><i>Objectives.</i>The purpose of this study is to investigate the age dependence of bilateral frontal electroencephalogram (EEG) coupling characteristics, and find potential age-independent depth of anesthesia monitoring indicators for the elderlies.<i>Approach.</i>We recorded bilateral forehead EEG data from 41 patients (ranged in 19-82 years old), and separated into three age groups: 18-40 years (<i>n</i>= 12); 40-65 years (<i>n</i>= 14), >65 years (<i>n</i>= 15). All these patients underwent desflurane maintained general anesthesia (GA). We analyzed the age-related EEG spectra, phase amplitude coupling (PAC), coherence and phase lag index (PLI) of EEG data in the states of awake, GA, and recovery.<i>Main results.</i>The frontal alpha power shows age dependence in the state of GA maintained by desflurane. Modulation index in slow oscillation-alpha and delta-alpha bands showed age dependence and state dependence in varying degrees, the PAC pattern also became less pronounced with increasing age. In the awake state, the coherence in delta, theta and alpha frequency bands were all significantly higher in the >65 years age group than in the 18-40 years age group (<i>p</i>< 0.05 for three frequency bands). The coherence in alpha-band was significantly enhanced in all age groups in GA (<i>p</i>< 0.01) and then decreased in recovery state. Notably, the PLI in the alpha band was able to significantly distinguish the three states of awake, GA and recovery (<i>p</i>< 0.01) and the results of PLI in delta and theta frequency bands had similar changes to those of coherence.<i>Significance.</i>We found the EEG coupling and synchronization between bilateral forehead are age-dependent. The PAC, coherence and PLI portray this age-dependence. The PLI and coherence based on bilateral frontal EEG functional connectivity measures and PAC based on frontal single-channel are closely associated with anesthesia-induced unconsciousness.</p>","PeriodicalId":20047,"journal":{"name":"Physiological measurement","volume":null,"pages":null},"PeriodicalIF":2.3000,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Age-dependent coupling characteristics of bilateral frontal EEG during desflurane anesthesia.\",\"authors\":\"Ziyang Li, Peiqi Wang, Licheng Han, Xinyu Hao, Weidong Mi, Li Tong, Zhenhu Liang\",\"doi\":\"10.1088/1361-6579/ad46e0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>Objectives.</i>The purpose of this study is to investigate the age dependence of bilateral frontal electroencephalogram (EEG) coupling characteristics, and find potential age-independent depth of anesthesia monitoring indicators for the elderlies.<i>Approach.</i>We recorded bilateral forehead EEG data from 41 patients (ranged in 19-82 years old), and separated into three age groups: 18-40 years (<i>n</i>= 12); 40-65 years (<i>n</i>= 14), >65 years (<i>n</i>= 15). All these patients underwent desflurane maintained general anesthesia (GA). We analyzed the age-related EEG spectra, phase amplitude coupling (PAC), coherence and phase lag index (PLI) of EEG data in the states of awake, GA, and recovery.<i>Main results.</i>The frontal alpha power shows age dependence in the state of GA maintained by desflurane. Modulation index in slow oscillation-alpha and delta-alpha bands showed age dependence and state dependence in varying degrees, the PAC pattern also became less pronounced with increasing age. In the awake state, the coherence in delta, theta and alpha frequency bands were all significantly higher in the >65 years age group than in the 18-40 years age group (<i>p</i>< 0.05 for three frequency bands). The coherence in alpha-band was significantly enhanced in all age groups in GA (<i>p</i>< 0.01) and then decreased in recovery state. Notably, the PLI in the alpha band was able to significantly distinguish the three states of awake, GA and recovery (<i>p</i>< 0.01) and the results of PLI in delta and theta frequency bands had similar changes to those of coherence.<i>Significance.</i>We found the EEG coupling and synchronization between bilateral forehead are age-dependent. The PAC, coherence and PLI portray this age-dependence. The PLI and coherence based on bilateral frontal EEG functional connectivity measures and PAC based on frontal single-channel are closely associated with anesthesia-induced unconsciousness.</p>\",\"PeriodicalId\":20047,\"journal\":{\"name\":\"Physiological measurement\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2024-05-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Physiological measurement\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1088/1361-6579/ad46e0\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"BIOPHYSICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physiological measurement","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1088/1361-6579/ad46e0","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOPHYSICS","Score":null,"Total":0}
引用次数: 0
摘要
研究目的本研究旨在探讨双侧额部脑电耦合特征的年龄依赖性,并寻找潜在的与年龄无关的老年人麻醉深度监测指标:我们记录了 41 名患者(年龄在 19-82 岁之间)的双侧额叶脑电图数据,并将其分为三个年龄组:18-40 岁(12 人);40-65 岁(14 人);大于 65 岁(15 人)。所有患者均接受了地氟醚全身麻醉。我们分析了清醒、全身麻醉(GA)和恢复状态下与年龄相关的脑电图频谱、相位振幅耦合(PAC)、相干性和相位滞后指数(PLI):在地氟醚维持的 GA 状态下,额叶α功率显示出年龄依赖性。慢振荡-α和δ-α波段的调制指数(MI)在不同程度上表现出年龄依赖性和状态依赖性,PAC模式也随着年龄的增加而变得不那么明显。在清醒状态下,65 岁以上年龄组的 delta、θ 和 alpha 频段的相干性都明显高于 18-40 岁年龄组(三个频段的 p <0.05)。在 GA 状态下,所有年龄组的阿尔法频段相干性都明显增强(P < 0.01),而在恢复状态下则下降。值得注意的是,α 频段的 PLI 能够显著区分清醒、GA 和恢复三种状态(p < 0.01),而 delta 和 theta 频段的 PLI 结果与相干性的变化相似:我们发现双侧前额的脑电耦合和同步与年龄有关。PAC、相干性和 PLI 反映了这种年龄依赖性。基于双侧额叶脑电图功能连接测量的 PLI 和相干性以及基于额叶单通道的 PAC 与麻醉诱导的昏迷密切相关。
Age-dependent coupling characteristics of bilateral frontal EEG during desflurane anesthesia.
Objectives.The purpose of this study is to investigate the age dependence of bilateral frontal electroencephalogram (EEG) coupling characteristics, and find potential age-independent depth of anesthesia monitoring indicators for the elderlies.Approach.We recorded bilateral forehead EEG data from 41 patients (ranged in 19-82 years old), and separated into three age groups: 18-40 years (n= 12); 40-65 years (n= 14), >65 years (n= 15). All these patients underwent desflurane maintained general anesthesia (GA). We analyzed the age-related EEG spectra, phase amplitude coupling (PAC), coherence and phase lag index (PLI) of EEG data in the states of awake, GA, and recovery.Main results.The frontal alpha power shows age dependence in the state of GA maintained by desflurane. Modulation index in slow oscillation-alpha and delta-alpha bands showed age dependence and state dependence in varying degrees, the PAC pattern also became less pronounced with increasing age. In the awake state, the coherence in delta, theta and alpha frequency bands were all significantly higher in the >65 years age group than in the 18-40 years age group (p< 0.05 for three frequency bands). The coherence in alpha-band was significantly enhanced in all age groups in GA (p< 0.01) and then decreased in recovery state. Notably, the PLI in the alpha band was able to significantly distinguish the three states of awake, GA and recovery (p< 0.01) and the results of PLI in delta and theta frequency bands had similar changes to those of coherence.Significance.We found the EEG coupling and synchronization between bilateral forehead are age-dependent. The PAC, coherence and PLI portray this age-dependence. The PLI and coherence based on bilateral frontal EEG functional connectivity measures and PAC based on frontal single-channel are closely associated with anesthesia-induced unconsciousness.
期刊介绍:
Physiological Measurement publishes papers about the quantitative assessment and visualization of physiological function in clinical research and practice, with an emphasis on the development of new methods of measurement and their validation.
Papers are published on topics including:
applied physiology in illness and health
electrical bioimpedance, optical and acoustic measurement techniques
advanced methods of time series and other data analysis
biomedical and clinical engineering
in-patient and ambulatory monitoring
point-of-care technologies
novel clinical measurements of cardiovascular, neurological, and musculoskeletal systems.
measurements in molecular, cellular and organ physiology and electrophysiology
physiological modeling and simulation
novel biomedical sensors, instruments, devices and systems
measurement standards and guidelines.