非编码 RNA 片段:基因组调控有多复杂?

IF 2.3 3区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Genome Pub Date : 2024-09-01 Epub Date: 2024-04-29 DOI:10.1139/gen-2023-0136
Miguel Ángel Velázquez-Flores, Ruth Ruiz Esparza-Garrido
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引用次数: 0

摘要

人类基因组是高度动态的,其中只有一小部分编码蛋白质,但大部分基因组都是转录的,这凸显了非编码 RNA 对细胞功能的重要性。此外,现在人们已经知道,在特定的细胞条件下,非编码 RNAs 片段的生成及其功能已被揭示出意想不到的作用机制,在某些情况下,与 microRNAs 或 Piwi-interacting RNAs 的生物生成途径和作用机制趋于一致。这让我们不禁要问,为什么细胞会产生这么多看似多余的分子来发挥类似的功能和调控看似趋同的过程?然而,非编码 RNAs 片段也可以发挥与适配体类似的功能,二级和三级构象决定了它们的功能。本研究回顾并分析了目前有关非编码 RNAs 片段的信息,描述了它们的结构和产生它们的生物途径,并特别强调了它们的细胞功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Fragments derived from non-coding RNAs: how complex is genome regulation?

The human genome is highly dynamic and only a small fraction of it codes for proteins, but most of the genome is transcribed, highlighting the importance of non-coding RNAs on cellular functions. In addition, it is now known the generation of non-coding RNA fragments under particular cellular conditions and their functions have revealed unexpected mechanisms of action, converging, in some cases, with the biogenic pathways and action machineries of microRNAs or Piwi-interacting RNAs. This led us to the question why the cell produces so many apparently redundant molecules to exert similar functions and regulate apparently convergent processes? However, non-coding RNAs fragments can also function similarly to aptamers, with secondary and tertiary conformations determining their functions. In the present work, it was reviewed and analyzed the current information about the non-coding RNAs fragments, describing their structure and biogenic pathways, with special emphasis on their cellular functions.

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来源期刊
Genome
Genome 生物-生物工程与应用微生物
CiteScore
5.30
自引率
3.20%
发文量
42
审稿时长
6-12 weeks
期刊介绍: Genome is a monthly journal, established in 1959, that publishes original research articles, reviews, mini-reviews, current opinions, and commentaries. Areas of interest include general genetics and genomics, cytogenetics, molecular and evolutionary genetics, developmental genetics, population genetics, phylogenomics, molecular identification, as well as emerging areas such as ecological, comparative, and functional genomics.
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