麦角草提取物在涉及泌尿生殖-肠轴的病理情况中的潜在治疗作用：对相关机制和介质的深入了解。

IF 2 4区医学 Q3 PHYSIOLOGY

Journal of Physiology and Pharmacology Pub Date : 2024-02-01 Epub Date: 2024-04-03 DOI:10.26402/jpp.2024.1.01

L Romano, L Napolitano, F Crocetto, C Sciorio, K Priadko, M Fonticelli, A Federico, M Romano, A G Gravina

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引用次数: 0

摘要

在这篇综述中，我们重点探讨了麦角草提取物在治疗下尿路病变方面的潜在治疗效果，肠道炎症可能在其中发挥了作用。为此，我们回顾了有关骨盆跨器官敏感性的现有证据，认为肠道炎症和菌群失调可能是影响下尿路的一种机制。此外，我们还回顾了支持麦角草提取物作为抗炎剂的临床和实验证据，强调了一些推定介质和机制的作用，这些作用可能使这种营养保健品适用于治疗 "难以治疗 "的下尿路疾病。

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The potential therapeutic role of Hericium erinaceus extract in pathologic conditions involving the urogenital-gut axis: insights into the involved mechanisms and mediators.

In this review we focused on the putative therapeutic effect of Hericium erinaceus extract in the treatment of pathologic conditions of the lower urinary tract in which intestinal inflammation may play a role. To this aim we reviewed the available evidence on pelvic cross-organ sensitization as a possible mechanism through which intestinal inflammation and dysbiosis may affect the lower urinary tract. Also, we reviewed the clinical and experimental evidence supporting the role of Hericium erinaceus extract as an anti-inflammatory agent highlighting the role of a number of putative mediators and mechanisms which might make this nutraceutical suitable for the management of 'difficult to treat' lower urinary tract disorders.

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来源期刊

Journal of Physiology and Pharmacology 医学-生理学

CiteScore

4.00

自引率

22.70%

发文量

审稿时长

6-12 weeks

期刊介绍： Journal of Physiology and Pharmacology publishes papers which fall within the range of basic and applied physiology, pathophysiology and pharmacology. The papers should illustrate new physiological or pharmacological mechanisms at the level of the cell membrane, single cells, tissues or organs. Clinical studies, that are of fundamental importance and have a direct bearing on the pathophysiology will also be considered. Letters related to articles published in The Journal with topics of general professional interest are welcome.