Carrie M Hersh, Menglan Pang, Deborah M Miller, Marisa P McGinley, Megan Hyland, Tjalf Ziemssen, Robin L Avila
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引用次数: 0
摘要
目的：评估纳他珠单抗与奥柯利珠单抗治疗患者神经系统疾病生活质量（Neuro-QoL）领域改善的时间。研究方法入选 MS PATHS 网络并开始接受纳他珠单抗或奥柯利珠单抗治疗的患者对身体功能、症状、情绪健康、认知功能和社交能力等神经-生活质量领域进行评分。结果显示在认知功能方面，纳他珠单抗的临床意义改善时间明显短于奥柯利珠单抗（事件时间比 [95% CI]：0.37 [0.24-0.57]；P 结论：纳妥珠单抗的临床意义改善时间明显短于奥柯利珠单抗：与奥克利珠单抗相比，纳他珠单抗在认知、睡眠和社会角色神经-QoL领域的临床意义改善时间更短。
Comparison of time to clinically meaningful improvement in quality of life in neurological disorders in patients treated with natalizumab versus ocrelizumab.
Aim: To assess time to improvement in Quality of Life in Neurological Disorders (Neuro-QoL) domains for patients treated with natalizumab versus ocrelizumab. Methods: Patients enrolled in the MS PATHS network who initiated treatment with either natalizumab or ocrelizumab rated the Neuro-QoL domains of physical function, symptoms, emotional health, cognitive function and social ability. Results: Time to clinically meaningful improvement was significantly shorter with natalizumab versus ocrelizumab for cognitive function (event time ratio [95% CI]: 0.37 [0.24-0.57]; p < 0.001), sleep disturbance (0.45 [0.28-0.72]; p = 0.001), social role participation (0.37 [0.21-0.66]; p = 0.001) and social role satisfaction (0.5 [0.31-0.8]; p = 0.004). Conclusion: Natalizumab had shorter time to clinically meaningful improvement in cognitive, sleep, and social role Neuro-QoL domains versus ocrelizumab.
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