小剂量溴酸钾可促进甲状腺切除大鼠缺血再灌注诱导的胃溃疡愈合

Q4 Medicine
Adeola Temitope Salami, Chidinma Chukwukaeme, Olawande Olagoke, Samuel Babafemi Olaleye
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引用次数: 0

摘要

甲状腺功能减退和甲状腺功能亢进都会影响胃溃疡的愈合。 甲状腺激素调节生长、能量代谢和线粒体氧化代谢。有资料表明,高剂量的异种生物会对甲状腺产生负面影响,但低剂量的异种生物在伤口愈合过程中的氧化还原作用和细胞相互作用仍不清楚。据记载,溴酸钾在高剂量时具有毒性,但有关其在低剂量时对不同甲状腺状态的活性的信息却十分匮乏,本研究对此进行了评估。60 只雄性 Wistar 大鼠(克,n=10)被随机分为两种情况:正常组、溃疡未处理组、溃疡用 12.5mg/kg p.o KBrO3 处理组和甲状腺切除组:甲状腺切除溃疡组、甲状腺切除溃疡用 KBrO3 处理组和甲状腺切除用甲状腺素(100µg/kg)处理组。甲状腺全切除术被用来模拟甲状腺功能减退症,缺血再灌注诱导的胃溃疡被用来监测愈合情况。在溃疡后第3天和第7天,对每日体重、甲状腺素水平、胃黏膜含量、氧化还原和钠泵活性以及其他肝脏和血液毒性指标进行检测。数据分析采用描述性统计和方差分析 α 0.05。暴露于溴酸盐的甲状腺功能减退大鼠的胃溃疡愈合能力增强,胃上皮水肿和炎症减轻;肝脏脂肪变性和肝周围炎症减轻。血液学变量和肝功能指标正常。胃和肝丙二醛水平降低。甲状腺素和溴酸钾治疗可能通过增加过氧化氢酶和巯基水平以及提高 Na+ K+ 泵活性来解决氧化还原和细胞毒性问题。我们的结论是,溴酸钾能促进甲状腺功能减退状态下的胃溃疡愈合,与甲状腺素治疗类似。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Low-dose Potassium bromate enhances ischemia-reperfusion-induced gastric ulcer healing in Thyroidectomised Rats.

Gastric ulcer healing is impaired in both hypothyroid and hyperthyroid conditions.  Thyroid hormones regulate growth, energy metabolism and mitochondrial oxidative metabolism. Xenobiotics have been documented to negatively impact the thyroid gland at high doses but the redox and cellular interactions at low doses during wound healing process remains unclear. Potassium bromate has been documented to be toxic at high doses but there is dearth of information on its activities at a low dose in varied thyroid states which was evaluated in this study. 60 male Wistar rats (g, n=10) were randomised into 2 conditions: Normal, ulcerated untreated, ulcerated treated with 12.5mg/kg p.o KBrO3 and thyroidectomised groups: thyroidectomised ulcerated, thyroidectomised ulcer treated with KBrO3 and thyroidectomised treated with thyroxine (100µg/kg) Total thyroidectomy was used to model hypothyroidism, and ischaemia-reperfusion-induced gastric ulcers were monitored for healing. Daily body weights, Levels of thyroxine, Gastric mucin content, redox and sodium pump activity were examined alongside other markers of hepatic and haematological toxicity by days 3 and 7 post ulceration. Data were analysed using descriptive statistics and ANOVA α 0.05. The bromate-exposed hypothyroid rats showed increased gastric ulcer healing potential with reduced gastric epithelial oedema and inflammation; hepatic steatosis, and periportal inflammation. Haematological variables and markers of hepatic functions were normal. There were reduced levels of gastric and hepatic malondialdehyde levels. Thyroxine and potassium bromate treatment resolved the redox and cellular toxicity possibly via increasing catalase and sulfhydryl levels and increased Na+ K+ pump activity. We conclude that potassium bromate enhanced gastric ulcer healing in hypothyroid state, similar to thyroxine treatment.

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来源期刊
Nigerian Journal of Physiological Sciences
Nigerian Journal of Physiological Sciences Medicine-Physiology (medical)
CiteScore
0.80
自引率
0.00%
发文量
23
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