测定各种自身免疫性甲状腺炎患者血清中α2-巨球蛋白的水平及其与自身抗体的可能联系。

Q3 Biochemistry, Genetics and Molecular Biology

Biomeditsinskaya khimiya Pub Date : 2024-04-01 DOI:10.18097/PBMC20247002125

R R Rahimova, A M Efendiyev, I J Shahverdiyeva, G S Dashdamirova, I A Kerimova

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引用次数: 0

摘要

对自身免疫性甲状腺炎（AIT）患者血清样本中的甲状腺过氧化物酶抗体（AB-TPO）、甲状腺球蛋白抗体（AB-TG）和α2-巨球蛋白（α2-MG）含量进行了研究。所有患者按年龄分为三组：25-35 岁、36-50 岁、51-65 岁。我们发现，AIT 患者的甲状腺全套参数发生了明显变化，但α2-MG 的平均浓度在不同年龄组的患者中没有明显变化。这可能是由于α2-MG与受体结合的能力下降，导致有缺陷的α2-MG复合物在血液循环中积累和滞留。

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Determination of the levels and possible associations of alpha2-macroglobulin with autoantibodies in the serum of patients with various forms of autoimmune thyroiditis.

Antibodies to thyroid peroxidase (AB-TPO), antibodies to thyroglobulin (AB-TG), and the content of α2-macroglobulin (α2-MG) have been studied in serum samples of patients with autoimmune thyroiditis (AIT). All the patients were divided into 3 groups depending on age: 25-35, 36-50, 51-65 years. We found a significant change in the thyroid panel parameters in AIT, but without significant changes in the average concentration of α2-MG in the age groups of patients. This may be due to the accumulation and retention of complexes of defective forms of α2-MG in the circulation associated with their decreased ability to bind to receptors.

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来源期刊

Biomeditsinskaya khimiya Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： The aim of the Russian-language journal "Biomeditsinskaya Khimiya" (Biomedical Chemistry) is to introduce the latest results obtained by scientists from Russia and other Republics of the Former Soviet Union. The Journal will cover all major areas of Biomedical chemistry, including neurochemistry, clinical chemistry, molecular biology of pathological processes, gene therapy, development of new drugs and their biochemical pharmacology, introduction and advertisement of new (biochemical) methods into experimental and clinical medicine etc. The Journal also publish review articles. All issues of journal usually contain invited reviews. Papers written in Russian contain abstract (in English).