高血压和颈动脉粥样硬化患者同型半胱氨酸和血压变化与左心室肥大的相关性

IF 1.9 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Alternative therapies in health and medicine Pub Date : 2025-01-01

Rui Liu, Yiwen Weng, Chunlian Zeng, Fei Dai, Jing Chen, Mengjiao Gou, Yalu Qin

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引用次数: 0

摘要

目的：通过非卧床血压检测推断高血压患者血压变异性和血Hcy的变化对心血管疾病进展风险的影响，对临床治疗具有积极意义。我们旨在探讨高血压合并颈动脉粥样硬化患者同型半胱氨酸和血压变化与左心室肥厚的相关性：选取2020年2月至2021年12月成都市金牛区人民医院收治的333例老年高血压患者作为研究对象。将其分为单纯高血压组和高血压合并颈动脉粥样硬化组。此外，两组还分为高血压合并左心室重构亚组和高血压无左心室重构亚组。血浆 Hcy 水平由 BECKMAN AU 680 自动生化分析仪测量。流动血压由 HINGMED ABP-03 监测系统测量。使用 GE LOGIQ E9 超声波仪测量内膜厚度。使用 GE LOGIQ E9 超声波测量左心室舒张功能：结果：高血压合并颈动脉粥样硬化组的血 Hcy、24 h 平均 SBP、24 h 平均 DBP、24 h SBP 变异系数和 24 h DBP 变异系数均显著高于单纯高血压组（P < .05）。此外，颈动脉粥样硬化组的 LVMI、E/A 和 E/e 均高于正常颈动脉组（P < .05）。高血压合并左心室重构亚组的内膜厚度、血 Hcy、24 小时平均 SBP、24 小时平均 DBP、24 小时 SBP 变异系数、24 小时 DBP 变异系数、E/A 和 E/e 均显著高于非左心室重构亚组（P < .05）。IMT与血Hcy、24 h SBP、24 h DBP、24 h SCV、24 h DCV、LVMI、E/A和E/e呈正相关（P < .05）：结论：高血压合并颈动脉粥样硬化患者的 Hcy 和 BPV 与左心室肥厚存在位置相关性。

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Correlation of Homocysteine and Blood Pressure Variability with Left Ventricular Hypertrophy in Patients with Hypertension and Carotid Atherosclerosis.

Objective: It is of positive significance for clinical management to infer the changes of BPV and blood Hcy in the risk of cardiovascular disease progression in patients with hypertension by ambulatory blood pressure test. We aimed to explore the correlation of homocysteine and blood pressure variability with left ventricular hypertrophy in patients with hypertension and carotid atherosclerosis.

Methods: A total of 333 elderly hypertensive patients admitted to Jinniu District People's Hospital in Chengdu from February 2020 to December 2021 were selected as the study subjects. They were divided into the pure hypertension group and hypertension combined with the carotid atherosclerosis group. In addition, the two groups were divided into the hypertension combined with left ventricular remodeling subgroup and the hypertension without left ventricular remodeling subgroup. Plasma Hcy levels were measured on a BECKMAN AU 680 automated biochemistry analyzer. Ambulatory blood pressure was measured by HINGMED ABP-03 monitoring system. IMT measurement was performed using a GE LOGIQ E9 ultrasound. Left ventricular diastolic function measurement was performed using a GE LOGIQ E9 ultrasound.

Results: Blood Hcy, 24-h mean SBP, 24-h mean DBP, 24-h SBP coefficient of variation, and 24-h DBP coefficient of variation were significantly higher in hypertension combined with the carotid atherosclerosis group than the pure hypertension group (P < .05). Moreover, LVMI, E/A, and E/e were greater in the carotid atherosclerosis group than in the normal carotid group (P < .05). IMT, blood Hcy, 24-h mean SBP, 24-h mean DBP, 24-h SBP coefficient of variation, 24-h DBP coefficient of variation, E/A, and E/e were significantly higher in the hypertensive combined with left ventricular remodeling subgroup than in the non-left ventricular remodeling subgroup (P < .05). IMT was positively correlated with blood Hcy, 24-h SBP, 24-h DBP, 24-h SCV, 24-h DCV, LVMI, E/A, and E/e (P < .05).

Conclusion: There was a position correlation of Hcy and BPV with left ventricular hypertrophy in patients with hypertension combined with carotid atherosclerosis.

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来源期刊

Alternative therapies in health and medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

0.90

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发文量

219

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