利用植物类黄酮对抗胰腺癌。

IF 4.6 3区 医学 Q1 NUTRITION & DIETETICS
Current Nutrition Reports Pub Date : 2024-09-01 Epub Date: 2024-05-03 DOI:10.1007/s13668-024-00545-9
Chengu Niu, Jing Zhang, Patrick I Okolo
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引用次数: 0

摘要

综述目的:本综述参考了过去十五年(2009-2024 年)发表的数据,总结了植物类黄酮对胰腺癌发生的潜在影响,并讨论了其可能的作用机制,以确定其作为抗癌剂的适用性:该综述发现,具有抗胰腺癌活性的植物类黄酮主要包括查耳酮、二氢查耳酮、黄烷醇、黄烷酮、黄酮、异黄酮、黄酮醇、异黄酮和黄烷壬醇。这些类黄酮大多具有抗增殖、促凋亡、抑制细胞周期、抗血管生成、抗炎、抗上皮-间质转化和抗转移等特性。某些类黄酮还能调节胰腺癌的自噬、免疫和葡萄糖摄取。有几种分子和信号通路与植物黄酮的药理活性有关,包括 AMP 活化蛋白激酶、丝裂原活化蛋白激酶、磷脂酰肌醇-3-激酶/蛋白激酶 B、核因子-κB、信号转导和转录激活因子 3、Smad3、表皮生长因子受体和血管内皮生长因子。本综述提供了强有力的证据,证明植物黄酮类化合物具有通过各种药理机制抑制实验动物胰腺癌发生的潜力。它们是一种很有希望用作辅助抗癌疗法的资源。不过,还需要对这些类黄酮进行随机对照临床试验。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Harnessing Plant Flavonoids to Fight Pancreatic Cancer.

Purpose of review: This review draws on the last fifteen years (2009-2024) of published data to summarize the potential effect of plant flavonoids on pancreatic carcinogenesis and discuss the possible mechanisms of action to establish their applicability as anti-cancer agents.

Recent findings: This review found that the plant flavonoids with anti-pancreatic cancer activity mainly include chalcones, dihydrochalcones, flavanols, flavanones, flavones, isoflavonoids, flavonols, isoflavones, and flavanonols. Most of these flavonoids have anti-proliferative, pro-apoptotic, cell cycle arrest, anti-angiogenic, anti-inflammatory, anti-epithelial-mesenchymal transition, and anti-metastatic properties. Some flavonoids can also regulate autophagy, immune and glucose uptake in the context of pancreatic cancer. Several molecules and signaling pathways are associated with the pharmacological activities of plant flavonoids, including AMP-activated protein kinase, mitogen-activated protein kinases, phosphatidylinositol-3-kinase/protein kinase B, nuclear factor-κB, signal transducer, and activator of transcription 3, Smad3, epidermal growth factor receptor, and vascular endothelial growth factor. This review provides strong evidence that plant flavonoids have potential against pancreatic carcinogenesis in experimental animals through various pharmacological mechanisms. They are a promising resource for use as adjuvant anti-cancer therapy. However, randomized controlled clinical trials with those flavonoids are needed.

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来源期刊
Current Nutrition Reports
Current Nutrition Reports Agricultural and Biological Sciences-Food Science
CiteScore
7.70
自引率
2.00%
发文量
59
期刊介绍: This journal aims to provide comprehensive review articles that emphasize significant developments in nutrition research emerging in recent publications. By presenting clear, insightful, balanced contributions by international experts, the journal intends to discuss the influence of nutrition on major health conditions such as diabetes, cardiovascular disease, cancer, and obesity, as well as the impact of nutrition on genetics, metabolic function, and public health. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas across the field. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. We also provide commentaries from well-known figures in the field, and an Editorial Board of more than 25 internationally diverse members reviews the annual table of contents, suggests topics of special importance to their country/region, and ensures that topics and current and include emerging research.
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