通过 omics 数据揭示生物控制真菌的代谢潜力:加强大规模应用战略的关键。

IF 3.3 2区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Haolin Yang, Xiuyun Wu, Caiyun Sun, Lushan Wang
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引用次数: 0

摘要

生物防治害虫和病原体因其绿色、安全和有效的特点而备受关注。然而,它在大规模应用中面临着效果不明显的困境。因此,基于大全息数据深入探索生物防治真菌的代谢潜力,对于全面系统地了解各种生物防治真菌的具体作用模式至关重要。本文分析了八种不同丝状真菌对胞外碳源和氮源降解、次级代谢产物(非核糖体肽、多酮合成酶)及其产物特征的偏好,以及胞外初级代谢和胞内次级代谢之间的转换关系,这些真菌都具有适合细菌病原体和植物病原线虫生物防治的特征。进一步明确了丝核菌(Paecilomyces lilacinus)编码大量水解酶,能够降解病原体保护屏障,可作为捕食性生物防治真菌直接应用于田间;而毛霉菌(Trichoderma)作为抗生素活性生物防治真菌,可在偏好的基质上形成优势菌株,并产生大量次生代谢产物以达到抗菌效果。通过阐明不同生物防治真菌所能达到的生物防治水平,我们为将它们应用于作物栖息地提供了理论基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Unraveling the metabolic potential of biocontrol fungi through omics data: a key to enhancing large-scaleapplication strategies.

Biological control of pests and pathogens has attracted much attention due to its green, safe and effective characteristics. However, it faces the dilemma of insignificant effects in large-scale applications. Therefore, an in-depth exploration of the metabolic potential of biocontrol fungi based on big omics data is crucial for a comprehensive and systematic understanding of the specific modes of action operated by various biocontrol fungi. This article analyzes the preferences for extracellular carbon and nitrogen source degradation, secondary metabolites (nonribosomal peptides, polyketide synthases) and their product characteristics and the conversion relationship between extracellular primary metabolism and intracellular secondary metabolism for eight different filamentous fungi with characteristics appropriate for the biological control of bacterial pathogens and phytopathogenic nematodes. Further clarification is provided that Paecilomyces lilacinus, encoding a large number of hydrolase enzymes capable of degrading pathogen protection barrier, can be directly applied in the field as a predatory biocontrol fungus, whereas Trichoderma, as an antibiosis-active biocontrol control fungus, can form dominant strains on preferred substrates and produce a large number of secondary metabolites to achieve antibacterial effects. By clarifying the levels of biological control achievable by different biocontrol fungi, we provide a theoretical foundation for their application to cropping habitats.

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来源期刊
Acta biochimica et biophysica Sinica
Acta biochimica et biophysica Sinica 生物-生化与分子生物学
CiteScore
5.00
自引率
5.40%
发文量
170
审稿时长
3 months
期刊介绍: Acta Biochimica et Biophysica Sinica (ABBS) is an internationally peer-reviewed journal sponsored by the Shanghai Institute of Biochemistry and Cell Biology (CAS). ABBS aims to publish original research articles and review articles in diverse fields of biochemical research including Protein Science, Nucleic Acids, Molecular Biology, Cell Biology, Biophysics, Immunology, and Signal Transduction, etc.
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