超越典型棕色脂肪细胞功能的分支

IF 27.7 1区生物学 Q1 CELL BIOLOGY

Cell metabolism Pub Date : 2024-05-07 DOI:10.1016/j.cmet.2024.04.011

Helaina Von Bank, Judith Simcox

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引用次数: 0

摘要

长期以来，棕色脂肪组织一直被认为是调节产热、体重设定点和葡萄糖稳态的器官。在2024年5月9日出版的《细胞》（Cell）杂志上，Verkerke等人发现了棕色脂肪组织的一种新功能，即把支链氨基酸加工成抗氧化代谢物，进入血液循环并调节肝脏中的胰岛素信号。

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Branching out beyond canonical brown adipocyte function

Brown adipose tissue has long been functionally characterized as an organ that regulates thermogenesis, body weight set point, and glucose homeostasis. In the May 9, 2024, issue of Cell, Verkerke et al. discover a novel function for brown adipose tissue in processing branched-chain amino acids into antioxidant metabolites that enter the circulation and regulate insulin signaling in the liver.

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来源期刊

Cell metabolism 生物-内分泌学与代谢

CiteScore

48.60

自引率

1.40%

发文量

173

审稿时长

2.5 months

期刊介绍： Cell Metabolism is a top research journal established in 2005 that focuses on publishing original and impactful papers in the field of metabolic research.It covers a wide range of topics including diabetes, obesity, cardiovascular biology, aging and stress responses, circadian biology, and many others. Cell Metabolism aims to contribute to the advancement of metabolic research by providing a platform for the publication and dissemination of high-quality research and thought-provoking articles.