多发性骨髓瘤中的 CAR T 细胞：经验教训

IF 81.1 1区医学 Q1 ONCOLOGY

Nature Reviews Clinical Oncology Pub Date : 2024-05-07 DOI:10.1038/s41571-024-00898-8

Vinay Prasad

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引用次数: 0

摘要

对于复发和/或难治性多发性骨髓瘤患者，嵌合抗原受体（CAR）T细胞疗法是否应在早期（既往接受过1-2种疗法后）使用，这个问题仍然没有答案。在此，笔者认为，由于使用了与总生存期缺乏稳健相关性的替代终点，以及次优对照组和进展后疗法的使用，限制了根据现有数据做出明确结论的能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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CAR T cells in multiple myeloma: lessons learned

The question of whether chimeric antigen receptor (CAR) T cell therapies should be used in earlier lines (after 1–2 prior lines of therapy) in patients with relapsed and/or refractory multiple myeloma remains unanswered. Herein, I argue that the use of surrogate end points that lack a robust correlation with overall survival, as well as suboptimal control arms and use of post-progression therapies, limit the ability to make definitive conclusions on the basis of the available data.

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来源期刊

Nature Reviews Clinical Oncology 医学-肿瘤学

CiteScore

99.40

自引率

0.40%

发文量

114

审稿时长

6-12 weeks

期刊介绍： Nature Reviews publishes clinical content authored by internationally renowned clinical academics and researchers, catering to readers in the medical sciences at postgraduate levels and beyond. Although targeted at practicing doctors, researchers, and academics within specific specialties, the aim is to ensure accessibility for readers across various medical disciplines. The journal features in-depth Reviews offering authoritative and current information, contextualizing topics within the history and development of a field. Perspectives, News & Views articles, and the Research Highlights section provide topical discussions, opinions, and filtered primary research from diverse medical journals.