PARP2 的特定和共享生物功能--PARP2 真的是 PARP1 的小弟弟吗？

IF 4.5 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Expert Reviews in Molecular Medicine Pub Date : 2024-05-03 DOI:10.1017/erm.2024.14

Magdolna Szántó, José Yélamos, Péter Bai

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引用次数: 0

摘要

PARP2 属于 ADP 核糖基转移酶（ART）家族，于 1999 年被发现，是一项千年发现。尽管 PARP2 最初被描述为一种 DNA 修复因子，但现在人们发现，PARP2 参与了多种生物过程的调节或执行，如炎症、致癌和癌症进展、新陈代谢或氧化应激相关疾病。在此，我们回顾了 PARP2 参与这些过程的情况，目的是了解哪些过程是 PARP2 所特有的，而 ART 家族的其他成员则没有。更好地了解 PARP2 在所有这些生物过程中的特定功能对于开发以 PARP 为中心的新型选择性疗法至关重要。

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Specific and shared biological functions of PARP2 – is PARP2 really a lil’ brother of PARP1?

PARP2, that belongs to the family of ADP-ribosyl transferase enzymes (ART), is a discovery of the millennium, as it was identified in 1999. Although PARP2 was described initially as a DNA repair factor, it is now evident that PARP2 partakes in the regulation or execution of multiple biological processes as inflammation, carcinogenesis and cancer progression, metabolism or oxidative stress-related diseases. Hereby, we review the involvement of PARP2 in these processes with the aim of understanding which processes are specific for PARP2, but not for other members of the ART family. A better understanding of the specific functions of PARP2 in all of these biological processes is crucial for the development of new PARP-centred selective therapies.

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来源期刊

Expert Reviews in Molecular Medicine BIOCHEMISTRY & MOLECULAR BIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL

CiteScore

7.40

自引率

1.60%

发文量

期刊介绍： Expert Reviews in Molecular Medicine is an innovative online journal featuring authoritative and timely Reviews covering gene therapy, immunotherapeutics, drug design, vaccines, genetic testing, pathogenesis, microbiology, genomics, molecular epidemiology and diagnostic techniques. We especially welcome reviews on translational aspects of molecular medicine, particularly those related to the application of new understanding of the molecular basis of disease to experimental medicine and clinical practice.