创伤性脊髓损伤的病理生物学:概述

IF 0.7 Q4 CLINICAL NEUROLOGY
William A. Florez-Perdomo, Andrés Cardona-Cruz Guillermo, Ezequiel García-Ballestas, Abigail Castilla-Martínez, Yancarlos Ramos-Villegas, Loraine Quintana-Pájaro, Tariq Janjua, Amit Agrawal, Luis Rafael Moscote-Salazar
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引用次数: 0

摘要

创伤性脊髓损伤(SCI)或创伤性脊髓病是一种破坏性神经系统疾病,给医疗系统带来沉重负担。有一些炎症和结构生物标志物具有明确的特征,有助于确定这种病症的管理和预后。实验室研究在确认脊髓损伤的存在方面显示出一定的作用。人们对脊髓损伤后发生的分子过程显然知之甚少,众所周知,要确定治疗目标以改善这类患者的预后,对分子过程的了解是必不可少的。许多研究都探讨了结构和炎症标志物以及一些结构和炎症生物标志物的作用。在本文中,我们回顾了脊柱损伤领域正在进行的研究以及生物标志物在这些患者的治疗中可能发挥的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pathobiology of traumatic spinal cord injury: an overview
Traumatic spinal cord injury (SCI) or traumatic myelopathy is a devastating neurological condition and a heavy burden on the health system. There are inflammatory and structural biomarkers with well-defined profiles, and useful for determining the management and prognosis of this pathology. Laboratory studies have shown some utility in confirming the existence of a spinal cord injury. Little knowledge about the molecular processes that occur after a SCI is evident, and it is well known that its understanding is dispensable to establish therapeutic targets that improve the outcomes for this type of patient. Many studies have explored the role of structural and inflammatory markers and some structural and inflammatory biomarkers. In the present article, we review the ongoing research in the field of spinal injury and possible role of biomarkers in the management of these patients.
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