William A. Florez-Perdomo, Andrés Cardona-Cruz Guillermo, Ezequiel García-Ballestas, Abigail Castilla-Martínez, Yancarlos Ramos-Villegas, Loraine Quintana-Pájaro, Tariq Janjua, Amit Agrawal, Luis Rafael Moscote-Salazar
{"title":"创伤性脊髓损伤的病理生物学:概述","authors":"William A. Florez-Perdomo, Andrés Cardona-Cruz Guillermo, Ezequiel García-Ballestas, Abigail Castilla-Martínez, Yancarlos Ramos-Villegas, Loraine Quintana-Pájaro, Tariq Janjua, Amit Agrawal, Luis Rafael Moscote-Salazar","doi":"10.1186/s41984-024-00282-9","DOIUrl":null,"url":null,"abstract":"Traumatic spinal cord injury (SCI) or traumatic myelopathy is a devastating neurological condition and a heavy burden on the health system. There are inflammatory and structural biomarkers with well-defined profiles, and useful for determining the management and prognosis of this pathology. Laboratory studies have shown some utility in confirming the existence of a spinal cord injury. Little knowledge about the molecular processes that occur after a SCI is evident, and it is well known that its understanding is dispensable to establish therapeutic targets that improve the outcomes for this type of patient. Many studies have explored the role of structural and inflammatory markers and some structural and inflammatory biomarkers. In the present article, we review the ongoing research in the field of spinal injury and possible role of biomarkers in the management of these patients.","PeriodicalId":72881,"journal":{"name":"Egyptian journal of neurosurgery","volume":null,"pages":null},"PeriodicalIF":0.7000,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Pathobiology of traumatic spinal cord injury: an overview\",\"authors\":\"William A. Florez-Perdomo, Andrés Cardona-Cruz Guillermo, Ezequiel García-Ballestas, Abigail Castilla-Martínez, Yancarlos Ramos-Villegas, Loraine Quintana-Pájaro, Tariq Janjua, Amit Agrawal, Luis Rafael Moscote-Salazar\",\"doi\":\"10.1186/s41984-024-00282-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Traumatic spinal cord injury (SCI) or traumatic myelopathy is a devastating neurological condition and a heavy burden on the health system. There are inflammatory and structural biomarkers with well-defined profiles, and useful for determining the management and prognosis of this pathology. Laboratory studies have shown some utility in confirming the existence of a spinal cord injury. Little knowledge about the molecular processes that occur after a SCI is evident, and it is well known that its understanding is dispensable to establish therapeutic targets that improve the outcomes for this type of patient. Many studies have explored the role of structural and inflammatory markers and some structural and inflammatory biomarkers. In the present article, we review the ongoing research in the field of spinal injury and possible role of biomarkers in the management of these patients.\",\"PeriodicalId\":72881,\"journal\":{\"name\":\"Egyptian journal of neurosurgery\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2024-05-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Egyptian journal of neurosurgery\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1186/s41984-024-00282-9\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Egyptian journal of neurosurgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s41984-024-00282-9","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Pathobiology of traumatic spinal cord injury: an overview
Traumatic spinal cord injury (SCI) or traumatic myelopathy is a devastating neurological condition and a heavy burden on the health system. There are inflammatory and structural biomarkers with well-defined profiles, and useful for determining the management and prognosis of this pathology. Laboratory studies have shown some utility in confirming the existence of a spinal cord injury. Little knowledge about the molecular processes that occur after a SCI is evident, and it is well known that its understanding is dispensable to establish therapeutic targets that improve the outcomes for this type of patient. Many studies have explored the role of structural and inflammatory markers and some structural and inflammatory biomarkers. In the present article, we review the ongoing research in the field of spinal injury and possible role of biomarkers in the management of these patients.