回到癌症中的叶酸代谢循环

IF 23.5 1区医学 Q1 ONCOLOGY

Nature cancer Pub Date : 2024-05-02 DOI:10.1038/s43018-024-00739-8

Younghwan Lee, Karen H. Vousden, Marc Hennequart

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引用次数: 0

摘要

代谢变化通过对癌细胞、肿瘤微环境和全身代谢的影响，导致癌症的发生和发展。丝氨酸代谢和一碳循环控制的改变已成为许多肿瘤类型发展的关键。在本综述中，我们将重点关注线粒体叶酸循环。我们讨论了最近的证据，即除了支持核苷酸合成外，线粒体叶酸代谢还通过支持抗氧化防御、线粒体蛋白质合成和过量甲酸盐溢出来促进转移。这些观察结果提供了潜在的治疗机会，包括通过饮食干预调节甲酸盐代谢，以及将循环叶酸循环代谢物用作癌症检测的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Cycling back to folate metabolism in cancer

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Cycling back to folate metabolism in cancer

Metabolic changes contribute to cancer initiation and progression through effects on cancer cells, the tumor microenvironment and whole-body metabolism. Alterations in serine metabolism and the control of one-carbon cycles have emerged as critical for the development of many tumor types. In this Review, we focus on the mitochondrial folate cycle. We discuss recent evidence that, in addition to supporting nucleotide synthesis, mitochondrial folate metabolism also contributes to metastasis through support of antioxidant defense, mitochondrial protein synthesis and the overflow of excess formate. These observations offer potential therapeutic opportunities, including the modulation of formate metabolism through dietary interventions and the use of circulating folate cycle metabolites as biomarkers for cancer detection. Vousden and colleagues discuss the multifactorial role of mitochondrial folate metabolism in cancer and metastasis and reflect on potential therapeutic opportunities.

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来源期刊

Nature cancer Medicine-Oncology

CiteScore

31.10

自引率

1.80%

发文量

129

期刊介绍： Cancer is a devastating disease responsible for millions of deaths worldwide. However, many of these deaths could be prevented with improved prevention and treatment strategies. To achieve this, it is crucial to focus on accurate diagnosis, effective treatment methods, and understanding the socioeconomic factors that influence cancer rates. Nature Cancer aims to serve as a unique platform for sharing the latest advancements in cancer research across various scientific fields, encompassing life sciences, physical sciences, applied sciences, and social sciences. The journal is particularly interested in fundamental research that enhances our understanding of tumor development and progression, as well as research that translates this knowledge into clinical applications through innovative diagnostic and therapeutic approaches. Additionally, Nature Cancer welcomes clinical studies that inform cancer diagnosis, treatment, and prevention, along with contributions exploring the societal impact of cancer on a global scale. In addition to publishing original research, Nature Cancer will feature Comments, Reviews, News & Views, Features, and Correspondence that hold significant value for the diverse field of cancer research.