硫化氢对男性和女性泌尿生殖系统的作用:从开始到现在

Sajad Salehiyeh, Ahmad Faisal Faiz, Mohammad Manzourolhojeh, Amir Mohammad Bagheri, Keivan Lorian
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引用次数: 0

摘要

众所周知,硫化氢(H2S)是自然界中的一种化学气体,可在人体不同器官中进行酶和非酶生物合成。一些研究已经证明了 H2S 在调节人体平衡方面的功能。此外,这些研究还从科学证据的各个方面展示了 H2S 的合成、测量、化学、保护作用和相互作用。此外,许多研究还证明了 H2S 对生殖器官和生殖系统的有益影响。根据各种研究,人们认识到在不同哺乳动物物种的男性和女性生殖系统中,H2S 生成酶和 H2S 的内源性生成均有表达。这篇综合综述的主要目的是评估这种气体递质对男性和女性泌尿生殖系统的潜在治疗影响,并寻找其潜在机制。这篇叙述性综述调查了 20 世纪 70 年代至 2022 年期间发表的文章。综述的主要重点是 H2S 对男性和女性泌尿生殖系统的影响。研究人员检索了 Medline、CINAHL、PubMed 和 Google scholar 数据库。本综述使用的关键词为 "硫化氢"、"H2S"、"泌尿生殖系统 "和 "泌尿生殖道"。大量研究表明,作为 H2S 供体的硫氢化钠(Na-HS)对男性和女性不孕症具有治疗和保护作用。此外,研究还发现,H2S 在改善精子参数等不同疾病方面发挥着重要作用。H2S 酶在泌尿生殖系统中的特异性定位为了解其在与该系统有关的各种疾病中的功能和作用提供了极好的机会。值得注意的是,H2S 已被证实可在内分泌器官中产生,并表现出多种活性。此外,重要的是要认识到 H2S 生物合成的改变与内分泌失调密切相关。因此,激素在调节 H2S 的产生方面起着关键作用,而 H2S 的合成途径可能有助于制定新的治疗策略。H2S 具有抗炎、抗细胞凋亡和抗氧化等药理作用,可用于治疗人类泌尿生殖系统疾病。此外,这种药物在改善各种男性和女性疾病的有害影响方面也大有可为。尽管临床研究有限,但研究表明,将 H2S 用作抗氧化剂源可改善泌尿生殖系统不同病症的不良影响。要确认这种成分在临床环境中的作用,还需要进行更多的临床研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The functions of hydrogen sulfide on the urogenital system of both males and females: from inception to the present

The functions of hydrogen sulfide on the urogenital system of both males and females: from inception to the present

Hydrogen sulfide (H2S) is known as a chemical gas in nature with both enzymatic and non-enzymatic biosynthesis in different human organs. A couple of studies have demonstrated the function of H2S in regulating the homeostasis of the human body. Additionally, they have shown its synthesis, measurement, chemistry, protective effects, and interaction in various aspects of scientific evidence. Furthermore, many researches have demonstrated the beneficial impacts of H2S on genital organs and systems. According to various studies, it is recognized that H2S-producing enzymes and the endogenous production of H2S are expressed in male and female reproductive systems in different mammalian species. The main goal of this comprehensive review is to assess the potential therapeutic impacts of this gasotransmitter in the male and female urogenital system and find underlying mechanisms of this agent. This narrative review investigated the articles that were published from the 1970s to 2022. The review’s primary focus is the impacts of H2S on the male and female urogenital system. Medline, CINAHL, PubMed, and Google scholar databases were searched. Keywords used in this review were “Hydrogen sulfide,” “H2S,” “urogenital system,” and “urogenital tract”. Numerous studies have demonstrated the therapeutic and protective effects of sodium hydrosulfide (Na-HS) as an H2S donor on male and female infertility disorders. Furthermore, it has been observed that H2S plays a significant role in improving different diseases such as ameliorating sperm parameters. The specific localization of H2S enzymes in the urogenital system provides an excellent opportunity to comprehend its function and role in various disorders related to this system. It is noteworthy that H2S has been demonstrated to be produced in endocrine organs and exhibit diverse activities. Moreover, it is important to recognize that alterations in H2S biosynthesis are closely linked to endocrine disorders. Therefore, hormones can be pivotal in regulating H2S production, and H2S synthesis pathways may aid in establishing novel therapeutic strategies. H2S possesses pharmacological effects on essential disorders, such as anti-inflammation, anti-apoptosis, and anti-oxidant activities, which render it a valuable therapeutic agent for human urogenital disease. Furthermore, this agent shows promise in ameliorating the detrimental effects of various male and female diseases. Despite the limited clinical research, studies have demonstrated that applying H2S as an anti-oxidant source could ameliorate adverse effects of different conditions in the urogenital system. More clinical studies are required to confirm the role of this component in clinical settings.

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