Luying Guo, Dr. Xing Guo, Huiquan Zuo, Heng Li, Dr. Fan Lv, Dr. Qinghua Wu, Prof. Lijuan Jiao, Prof. Erhong Hao
{"title":"正交α-介质连接双 BODIPY 光敏剂展示了有效的双光子荧光成像和光动力疗法","authors":"Luying Guo, Dr. Xing Guo, Huiquan Zuo, Heng Li, Dr. Fan Lv, Dr. Qinghua Wu, Prof. Lijuan Jiao, Prof. Erhong Hao","doi":"10.1002/cptc.202400100","DOIUrl":null,"url":null,"abstract":"<p>Hypoxic tumor microenvironments pose significant challenges to the clinical translation of cancer photodynamic therapy (PDT). While heavy atom-free Type-I boron dipyrromethenes (BODIPYs) photosensitizers can alleviate this challenge by reducing oxygen dependency, but they remain scarce. Herein, heavy-atom-free <i>α,meso</i>-linked bisBODIPYs were designed and synthesized. These bisBODIPYs exhibit remarkable red-shifted emission (λemmax ~670 nm), large Stokes shifts (~4480 cm<sup>−1</sup>) and they are capable of producing both superoxide anion (O<sub>2</sub>⋅<sup>−</sup>) and singlet oxygen (<sup>1</sup>O<sub>2</sub>) in solution and cells. Additionally, they offer a wide PDT treatment window, ranging from 0.26 to 83.5 μM. Furthermore, these bisBODIPYs also demonstrate superior two-photon fluorescence, promising for surgical navigation and integrating diagnosis with treatment.</p>","PeriodicalId":10108,"journal":{"name":"ChemPhotoChem","volume":"8 9","pages":""},"PeriodicalIF":3.0000,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Orthogonal α-meso-Linked bisBODIPY Photosensitizers Demonstrate Effective Two-Photon Fluorescence Imaging and Photodynamic Therapy\",\"authors\":\"Luying Guo, Dr. Xing Guo, Huiquan Zuo, Heng Li, Dr. Fan Lv, Dr. Qinghua Wu, Prof. Lijuan Jiao, Prof. Erhong Hao\",\"doi\":\"10.1002/cptc.202400100\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Hypoxic tumor microenvironments pose significant challenges to the clinical translation of cancer photodynamic therapy (PDT). While heavy atom-free Type-I boron dipyrromethenes (BODIPYs) photosensitizers can alleviate this challenge by reducing oxygen dependency, but they remain scarce. Herein, heavy-atom-free <i>α,meso</i>-linked bisBODIPYs were designed and synthesized. These bisBODIPYs exhibit remarkable red-shifted emission (λemmax ~670 nm), large Stokes shifts (~4480 cm<sup>−1</sup>) and they are capable of producing both superoxide anion (O<sub>2</sub>⋅<sup>−</sup>) and singlet oxygen (<sup>1</sup>O<sub>2</sub>) in solution and cells. Additionally, they offer a wide PDT treatment window, ranging from 0.26 to 83.5 μM. Furthermore, these bisBODIPYs also demonstrate superior two-photon fluorescence, promising for surgical navigation and integrating diagnosis with treatment.</p>\",\"PeriodicalId\":10108,\"journal\":{\"name\":\"ChemPhotoChem\",\"volume\":\"8 9\",\"pages\":\"\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2024-04-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ChemPhotoChem\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/cptc.202400100\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ChemPhotoChem","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cptc.202400100","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
The Orthogonal α-meso-Linked bisBODIPY Photosensitizers Demonstrate Effective Two-Photon Fluorescence Imaging and Photodynamic Therapy
Hypoxic tumor microenvironments pose significant challenges to the clinical translation of cancer photodynamic therapy (PDT). While heavy atom-free Type-I boron dipyrromethenes (BODIPYs) photosensitizers can alleviate this challenge by reducing oxygen dependency, but they remain scarce. Herein, heavy-atom-free α,meso-linked bisBODIPYs were designed and synthesized. These bisBODIPYs exhibit remarkable red-shifted emission (λemmax ~670 nm), large Stokes shifts (~4480 cm−1) and they are capable of producing both superoxide anion (O2⋅−) and singlet oxygen (1O2) in solution and cells. Additionally, they offer a wide PDT treatment window, ranging from 0.26 to 83.5 μM. Furthermore, these bisBODIPYs also demonstrate superior two-photon fluorescence, promising for surgical navigation and integrating diagnosis with treatment.
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