丘脑下 25 区:它对压力荷尔蒙皮质醇的反应及其对狨猴食欲动机的相反影响

IF 4.3 2区 医学 Q1 NEUROSCIENCES
Rana Banai Tizkar, Lauren McIver, Christian Michael Wood , Angela Charlotte Roberts
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引用次数: 0

摘要

胼胝体尾下前扣带回皮层(scACC)的异常活动与抑郁和焦虑症状有关,其正常化是成功治疗反应的潜在生物标志物。尽管人们知道扣带回皮质通过其丰富的矿物质皮质激素和糖皮质激素受体的表达对压力介导的过程产生影响,但它在情绪处理和心理健康中的功能尚未完全明了。在此,我们研究了scACC内的25区(scACC-25)与应激激素皮质醇之间在失神和焦虑样行为方面的因果相互作用。此外,我们还研究了在瞬时药理失活和过度失活的情况下,scACC-25 在享乐能力和动机中的整体作用。结果表明,scACC-25 中皮质醇的局部增加会迅速诱发预期性失神和对不确定威胁的反应性增加。scACC-25的单独失活和过度失活分别增加和减少了动机和享乐能力,这可能是通过不同的潜在机制实现的。这些数据共同表明,scACC-25区域在消费行为和动机行为中起着因果作用,并对压力荷尔蒙皮质醇产生快速反应,从而介导失乐症和焦虑样行为。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Subcallosal area 25: Its responsivity to the stress hormone cortisol and its opposing effects on appetitive motivation in marmosets

Aberrant activity in caudal subcallosal anterior cingulate cortex (scACC) is implicated in depression and anxiety symptomatology, with its normalisation a putative biomarker of successful treatment response. The function of scACC in emotion processing and mental health is not fully understood despite its known influence on stress-mediated processes through its rich expression of mineralocorticoid and glucocorticoid receptors. Here we examine the causal interaction between area 25 within scACC (scACC-25) and the stress hormone, cortisol, in the context of anhedonia and anxiety-like behaviour. In addition, the overall role of scACC-25 in hedonic capacity and motivation is investigated under transient pharmacological inactivation and overactivation. The results suggest that a local increase of cortisol in scACC-25 shows a rapid induction of anticipatory anhedonia and increased responsiveness to uncertain threat. Separate inactivation and overactivation of scACC-25 increased and decreased motivation and hedonic capacity, respectively, likely through different underlying mechanisms. Together, these data show that area scACC-25 has a causal role in consummatory and motivational behaviour and produces rapid responses to the stress hormone cortisol, that mediates anhedonia and anxiety-like behaviour.

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来源期刊
Neurobiology of Stress
Neurobiology of Stress Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
9.40
自引率
4.00%
发文量
74
审稿时长
48 days
期刊介绍: Neurobiology of Stress is a multidisciplinary journal for the publication of original research and review articles on basic, translational and clinical research into stress and related disorders. It will focus on the impact of stress on the brain from cellular to behavioral functions and stress-related neuropsychiatric disorders (such as depression, trauma and anxiety). The translation of basic research findings into real-world applications will be a key aim of the journal. Basic, translational and clinical research on the following topics as they relate to stress will be covered: Molecular substrates and cell signaling, Genetics and epigenetics, Stress circuitry, Structural and physiological plasticity, Developmental Aspects, Laboratory models of stress, Neuroinflammation and pathology, Memory and Cognition, Motivational Processes, Fear and Anxiety, Stress-related neuropsychiatric disorders (including depression, PTSD, substance abuse), Neuropsychopharmacology.
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