J. Guillou , J. Duprez , R. Nabbout , A. Kaminska , S. Napuri , C. Gomes , M. Kuchenbuch , P. Sauleau
{"title":"儿童脑电图节律的半球间一致性：胼胝体发育不良的成熟和分化","authors":"J. Guillou , J. Duprez , R. Nabbout , A. Kaminska , S. Napuri , C. Gomes , M. Kuchenbuch , P. Sauleau","doi":"10.1016/j.neucli.2024.102981","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><p>To evaluate the evolution of interhemispheric coherences (ICo) in background and spindle frequency bands during childhood and use it to identify individuals with corpus callosum dysgenesis (CCd).</p></div><div><h3>Methods</h3><p>A monocentric cohort of children aged from 0.25 to 15 years old, consisting of 13 children with CCd and 164 without, was analyzed. The ICo of background activity (ICO<sub>BckgrdA</sub>), sleep spindles (ICO<sub>spindles</sub>), and their sum (<sub>s</sub>ICO) were calculated. The impact of age, gender, and CC status on the ICo was evaluated, and the <sub>s</sub>ICO was used to discriminate children with or without CCd.</p></div><div><h3>Results</h3><p>ICO<sub>BckgrdA</sub>, ICO<sub>spindles</sub> and sICO increased significantly with age without any effect of gender (<em>p</em> < 10<sup>−4</sup>), in both groups. The regression equations of the different ICo were stronger, with adjusted R2 values of 0.54, 0.35, and 0.57, respectively. The ICo was lower in children with CCd compared to those without CCd (<em>p</em> < 10<sup>−4</sup> for all comparisons). The area under the precision recall curves for predicting CCd using <sub>s</sub>ICO was 0.992 with 98.9 % sensitivity and 87.5 % specificity.</p></div><div><h3>Discussion</h3><p>ICo of spindles and background activity evolve in parallel to brain maturation and depends on the integrity of the corpus callosum. sICO could be an effective diagnostic biomarker for screening children with interhemispheric dysfunction.</p></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"54 3","pages":"Article 102981"},"PeriodicalIF":2.7000,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Interhemispheric coherence of EEG rhythms in children: Maturation and differentiation in corpus callosum dysgenesis\",\"authors\":\"J. Guillou , J. Duprez , R. Nabbout , A. Kaminska , S. Napuri , C. Gomes , M. Kuchenbuch , P. Sauleau\",\"doi\":\"10.1016/j.neucli.2024.102981\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objectives</h3><p>To evaluate the evolution of interhemispheric coherences (ICo) in background and spindle frequency bands during childhood and use it to identify individuals with corpus callosum dysgenesis (CCd).</p></div><div><h3>Methods</h3><p>A monocentric cohort of children aged from 0.25 to 15 years old, consisting of 13 children with CCd and 164 without, was analyzed. The ICo of background activity (ICO<sub>BckgrdA</sub>), sleep spindles (ICO<sub>spindles</sub>), and their sum (<sub>s</sub>ICO) were calculated. The impact of age, gender, and CC status on the ICo was evaluated, and the <sub>s</sub>ICO was used to discriminate children with or without CCd.</p></div><div><h3>Results</h3><p>ICO<sub>BckgrdA</sub>, ICO<sub>spindles</sub> and sICO increased significantly with age without any effect of gender (<em>p</em> < 10<sup>−4</sup>), in both groups. The regression equations of the different ICo were stronger, with adjusted R2 values of 0.54, 0.35, and 0.57, respectively. The ICo was lower in children with CCd compared to those without CCd (<em>p</em> < 10<sup>−4</sup> for all comparisons). The area under the precision recall curves for predicting CCd using <sub>s</sub>ICO was 0.992 with 98.9 % sensitivity and 87.5 % specificity.</p></div><div><h3>Discussion</h3><p>ICo of spindles and background activity evolve in parallel to brain maturation and depends on the integrity of the corpus callosum. sICO could be an effective diagnostic biomarker for screening children with interhemispheric dysfunction.</p></div>\",\"PeriodicalId\":19134,\"journal\":{\"name\":\"Neurophysiologie Clinique/Clinical Neurophysiology\",\"volume\":\"54 3\",\"pages\":\"Article 102981\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2024-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neurophysiologie Clinique/Clinical Neurophysiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S098770532400039X\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurophysiologie Clinique/Clinical Neurophysiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S098770532400039X","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Interhemispheric coherence of EEG rhythms in children: Maturation and differentiation in corpus callosum dysgenesis
Objectives
To evaluate the evolution of interhemispheric coherences (ICo) in background and spindle frequency bands during childhood and use it to identify individuals with corpus callosum dysgenesis (CCd).
Methods
A monocentric cohort of children aged from 0.25 to 15 years old, consisting of 13 children with CCd and 164 without, was analyzed. The ICo of background activity (ICOBckgrdA), sleep spindles (ICOspindles), and their sum (sICO) were calculated. The impact of age, gender, and CC status on the ICo was evaluated, and the sICO was used to discriminate children with or without CCd.
Results
ICOBckgrdA, ICOspindles and sICO increased significantly with age without any effect of gender (p < 10−4), in both groups. The regression equations of the different ICo were stronger, with adjusted R2 values of 0.54, 0.35, and 0.57, respectively. The ICo was lower in children with CCd compared to those without CCd (p < 10−4 for all comparisons). The area under the precision recall curves for predicting CCd using sICO was 0.992 with 98.9 % sensitivity and 87.5 % specificity.
Discussion
ICo of spindles and background activity evolve in parallel to brain maturation and depends on the integrity of the corpus callosum. sICO could be an effective diagnostic biomarker for screening children with interhemispheric dysfunction.
期刊介绍：
Neurophysiologie Clinique / Clinical Neurophysiology (NCCN) is the official organ of the French Society of Clinical Neurophysiology (SNCLF). This journal is published 6 times a year, and is aimed at an international readership, with articles written in English. These can take the form of original research papers, comprehensive review articles, viewpoints, short communications, technical notes, editorials or letters to the Editor. The theme is the neurophysiological investigation of central or peripheral nervous system or muscle in healthy humans or patients. The journal focuses on key areas of clinical neurophysiology: electro- or magneto-encephalography, evoked potentials of all modalities, electroneuromyography, sleep, pain, posture, balance, motor control, autonomic nervous system, cognition, invasive and non-invasive neuromodulation, signal processing, bio-engineering, functional imaging.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
