M. Pintanel-Raymundo , S. Menao-Guillén , J.J. Perales-Afán , A. García-Gutiérrez , I. Moreno-Gázquez , M. Julián-Ansón , M. Ramos-Álvarez , S. Olivera-González , I. Gutiérrez-Cía , M.A. Torralba-Cabeza
{"title":"SARS-CoV-2感染中SERPINA1基因表达分析:一项新的生物标志物研究。","authors":"M. Pintanel-Raymundo , S. Menao-Guillén , J.J. Perales-Afán , A. García-Gutiérrez , I. Moreno-Gázquez , M. Julián-Ansón , M. Ramos-Álvarez , S. Olivera-González , I. Gutiérrez-Cía , M.A. Torralba-Cabeza","doi":"10.1016/j.rce.2024.03.002","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p>The <em>SERPINA1</em> gene encodes the protein Alpha-1 Antitrypsin (AAT1). Possible imbalances between the concentrations of proteases and antiproteases (AAT1) can lead to the development of serious pulmonary and extrapulmonary pathologies. In this work we study the importance of this possible imbalance in patients with COVID-19.</p></div><div><h3>Objectives</h3><p>To correlate the severity of the symptoms of SARS-CoV-2 infection with the AAT1 concentrations at diagnosis of the disease.</p></div><div><h3>Methods</h3><p>An observational, prospective, cross-sectional, non-interventional, analytical study was carried out where 181 cases with COVID-19 admitted to the “Lozano Blesa” University Clinical Hospital of Zaragoza were selected. The concentration of AAT1 was studied in all of them and this was correlated with the clinical aspects and biochemical parameters at hospital admission.</p></div><div><h3>Results</h3><p>141 cases corresponded to patients with severe COVID and 40 patients with mild COVID. AAT1 levels were positively correlated with the days of hospitalization, severity, C-Reactive Protein, ferritin, admission to Intensive Care, and death, and presented a negative correlation with the number of lymphocytes/mm3. AAT1 concentrations higher than 237.5<!--> <!-->mg/dL allowed the patient to be classified as “severe” (S72%; E78%) and 311.5<!--> <!-->mg/dL were associated with the risk of admission to Intensive Care or Exitus (S67%;E79%).</p></div><div><h3>Conclusions</h3><p>Levels of the SERPINA1 gene expression product, AAT1, correlate with the severity of COVID-19 patients at diagnosis of the disease, being useful as a prognostic biomarker.</p></div>","PeriodicalId":21223,"journal":{"name":"Revista clinica espanola","volume":null,"pages":null},"PeriodicalIF":2.3000,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Análisis de la expresión del gen SERPINA1 en la infección por SARS-CoV-2: estudio de un nuevo biomarcador\",\"authors\":\"M. Pintanel-Raymundo , S. Menao-Guillén , J.J. Perales-Afán , A. García-Gutiérrez , I. Moreno-Gázquez , M. Julián-Ansón , M. Ramos-Álvarez , S. Olivera-González , I. Gutiérrez-Cía , M.A. Torralba-Cabeza\",\"doi\":\"10.1016/j.rce.2024.03.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><p>The <em>SERPINA1</em> gene encodes the protein Alpha-1 Antitrypsin (AAT1). Possible imbalances between the concentrations of proteases and antiproteases (AAT1) can lead to the development of serious pulmonary and extrapulmonary pathologies. In this work we study the importance of this possible imbalance in patients with COVID-19.</p></div><div><h3>Objectives</h3><p>To correlate the severity of the symptoms of SARS-CoV-2 infection with the AAT1 concentrations at diagnosis of the disease.</p></div><div><h3>Methods</h3><p>An observational, prospective, cross-sectional, non-interventional, analytical study was carried out where 181 cases with COVID-19 admitted to the “Lozano Blesa” University Clinical Hospital of Zaragoza were selected. The concentration of AAT1 was studied in all of them and this was correlated with the clinical aspects and biochemical parameters at hospital admission.</p></div><div><h3>Results</h3><p>141 cases corresponded to patients with severe COVID and 40 patients with mild COVID. AAT1 levels were positively correlated with the days of hospitalization, severity, C-Reactive Protein, ferritin, admission to Intensive Care, and death, and presented a negative correlation with the number of lymphocytes/mm3. AAT1 concentrations higher than 237.5<!--> <!-->mg/dL allowed the patient to be classified as “severe” (S72%; E78%) and 311.5<!--> <!-->mg/dL were associated with the risk of admission to Intensive Care or Exitus (S67%;E79%).</p></div><div><h3>Conclusions</h3><p>Levels of the SERPINA1 gene expression product, AAT1, correlate with the severity of COVID-19 patients at diagnosis of the disease, being useful as a prognostic biomarker.</p></div>\",\"PeriodicalId\":21223,\"journal\":{\"name\":\"Revista clinica espanola\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2024-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista clinica espanola\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0014256524000651\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista clinica espanola","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0014256524000651","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Análisis de la expresión del gen SERPINA1 en la infección por SARS-CoV-2: estudio de un nuevo biomarcador
Introduction
The SERPINA1 gene encodes the protein Alpha-1 Antitrypsin (AAT1). Possible imbalances between the concentrations of proteases and antiproteases (AAT1) can lead to the development of serious pulmonary and extrapulmonary pathologies. In this work we study the importance of this possible imbalance in patients with COVID-19.
Objectives
To correlate the severity of the symptoms of SARS-CoV-2 infection with the AAT1 concentrations at diagnosis of the disease.
Methods
An observational, prospective, cross-sectional, non-interventional, analytical study was carried out where 181 cases with COVID-19 admitted to the “Lozano Blesa” University Clinical Hospital of Zaragoza were selected. The concentration of AAT1 was studied in all of them and this was correlated with the clinical aspects and biochemical parameters at hospital admission.
Results
141 cases corresponded to patients with severe COVID and 40 patients with mild COVID. AAT1 levels were positively correlated with the days of hospitalization, severity, C-Reactive Protein, ferritin, admission to Intensive Care, and death, and presented a negative correlation with the number of lymphocytes/mm3. AAT1 concentrations higher than 237.5 mg/dL allowed the patient to be classified as “severe” (S72%; E78%) and 311.5 mg/dL were associated with the risk of admission to Intensive Care or Exitus (S67%;E79%).
Conclusions
Levels of the SERPINA1 gene expression product, AAT1, correlate with the severity of COVID-19 patients at diagnosis of the disease, being useful as a prognostic biomarker.
期刊介绍:
Revista Clínica Española published its first issue in 1940 and is the body of expression of the Spanish Society of Internal Medicine (SEMI).
The journal fully endorses the goals of updating knowledge and facilitating the acquisition of key developments in internal medicine applied to clinical practice. Revista Clínica Española is subject to a thorough double blind review of the received articles written in Spanish or English. Nine issues are published each year, including mostly originals, reviews and consensus documents.