早产儿溶血疗法的历史回顾

IF 1.5 Q3 OBSTETRICS & GYNECOLOGY
Tijn van Winden , Carolien Roos , Ben W. Mol , E. Pajkrt , Martijn A. Oudijk
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引用次数: 0

摘要

早产是临床产科的一项重大挑战,需要采取有效的策略来降低相关的死亡率和发病率风险。旨在抑制子宫收缩的催产药物是应对这一挑战的关键环节。尽管经过多年的广泛研究,但确定最有效的催产药物仍是一项复杂的任务,这促使人们更好地了解自发性早产的潜在机制,并记录有意义的结果测量。本文全面回顾了过去一个世纪中采用的各种过时和现行的促溶血药物疗法,研究了这些疗法的历史背景以及在开发和采用过程中遇到的当代挑战。对历史上的争论和进展的研究凸显了引入新疗法的复杂性。在继续寻找有效溶解剂的同时,人们也对其在产科护理中的实际益处提出了质疑,并认为有必要对其进行持续探索。目前的研究存在方法上的局限性,这强调了设计良好的随机对照试验的重要性,这些试验应具有可靠的终点和较长的随访期。针对这些复杂性,越来越多的人开始考虑转向旨在解决早产根源的预防策略。这种潜在的转变可能会提供一种比单纯依赖催产药来推迟分娩开始时间更有效的方法。最终,要有效控制濒临早产的威胁,就必须不断调查、创新,并愿意重新评估各种策略,以追求对母亲、新生儿和儿童长期健康的最佳结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A historical narrative review through the field of tocolysis in threatened preterm birth

Preterm birth presents a significant challenge in clinical obstetrics, requiring effective strategies to reduce associated mortality and morbidity risks. Tocolytic drugs, aimed at inhibiting uterine contractions, are a key aspect of addressing this challenge. Despite extensive research over many years, determining the most effective tocolytic agents remains a complex task, prompting better understanding of the underlying mechanisms of spontaneous preterm birth and recording meaningful outcome measures. This paper provides a comprehensive review of various obsolete and current tocolytic drug regimens that were instituted over the past century, examining both historical contexts and contemporary challenges in their development and adoption. The examination of historical debates and advancements highlights the complexity of introducing new therapies. While the search for effective tocolytics continues, questions arise regarding their actual benefits in obstetric care and the necessity for ongoing exploration. The presence of methodological limitations in current research emphasizes the importance of well-designed randomized controlled trials with robust endpoints and extended follow-up periods.In response to these complexities, the consideration of shifting towards prevention strategies aimed at addressing the root causes of preterm labor becomes more and more evident. This potential shift may offer a more effective approach than relying solely on tocolytics to delay labor initiation.Ultimately, effectively managing threatened preterm birth necessitates ongoing investigation, innovation, and a willingness to reassess strategies in pursuit of optimal outcomes for mothers, neonates, and long-term child health.

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来源期刊
CiteScore
2.20
自引率
0.00%
发文量
31
审稿时长
58 days
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