癌症干细胞的特征

IF 19.8 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2024-05-02 DOI:10.1016/j.stem.2024.04.004

Jia-Jian Loh, Stephanie Ma

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引用次数: 0

摘要

癌症干细胞被认为是肿瘤发展的关键组成部分。癌症干细胞以前被称为 "癌症干细胞"（CSCs），并被认为是一种具有严格分层组织的稀有群体。这一启示强调了重新评估癌症干性特征的必要性。在此，我们总结了用于识别和描述这些细胞状态的技术，并讨论了它们的决定性特征和新出现的特征，以及它们的赋能特征和相关特征。我们还强调了这一研究领域未来的潜在方向。

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Hallmarks of cancer stemness

Cancer stemness is recognized as a key component of tumor development. Previously coined “cancer stem cells” (CSCs) and believed to be a rare population with rigid hierarchical organization, there is good evidence to suggest that these cells exhibit a plastic cellular state influenced by dynamic CSC-niche interplay. This revelation underscores the need to reevaluate the hallmarks of cancer stemness. Herein, we summarize the techniques used to identify and characterize the state of these cells and discuss their defining and emerging hallmarks, along with their enabling and associated features. We also highlight potential future directions in this field of research.

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.