钙化软骨间充质肿瘤中的血小板衍生生长因子受体α（PDGFRA）与泛素特异性肽酶 8（USP8）融合，其中 t(4;15)(q12;q21)是唯一的畸变。

IF 2.6 4区医学 Q2 GENETICS & HEREDITY

Cancer Genomics & Proteomics Pub Date : 2024-04-27 DOI:10.21873/cgp.20444

Ioannis Panagopoulos, Kristin Andersen, Ludmila Gorunova, Ingvild Lobmaier

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引用次数: 0

摘要

钙化软骨间充质肿瘤 "一词是在 2021 年提出的，用来描述一组具有各种形态特征的肿瘤，包括软骨或软骨基质的形成。这些肿瘤经常携带嵌合基因，其中 5'end 伴侣基因是纤维粘连蛋白 1，3'end 伴侣基因编码受体酪氨酸激酶。我们的研究探讨了钙化软骨间充质肿瘤中血小板衍生生长因子受体α（PDGFRA）和泛素特异性肽酶8（USP8）基因的融合。

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Fusion of Platelet Derived Growth Factor Receptor Alpha (PDGFRA) With Ubiquitin Specific Peptidase 8 (USP8) in a Calcified Chondroid Mesenchymal Neoplasm Harboring t(4;15)(q12;q21) as a Sole Aberration.

The term "calcified chondroid mesenchymal neoplasm" was introduced in 2021 to describe a group of tumors characterized by various morphological features, including the formation of cartilage or chondroid matrix. These tumors frequently carry chimeric genes where the 5'-end partner gene is fibronectin 1 and the 3'-end partner gene codes for receptor tyrosine kinase. Our study explores fusion of the genes platelet-derived growth factor receptor alpha (PDGFRA) and ubiquitin-specific peptidase 8 (USP8) in calcified chondroid mesenchymal neoplasm.

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来源期刊

Cancer Genomics & Proteomics ONCOLOGY-GENETICS & HEREDITY

CiteScore

5.00

自引率

8.00%

发文量

期刊介绍： Cancer Genomics & Proteomics (CGP) is an international peer-reviewed journal designed to publish rapidly high quality articles and reviews on the application of genomic and proteomic technology to basic, experimental and clinical cancer research. In this site you may find information concerning the editorial board, editorial policy, issue contents, subscriptions, submission of manuscripts and advertising. The first issue of CGP circulated in January 2004. Cancer Genomics & Proteomics is a journal of the International Institute of Anticancer Research. From January 2013 CGP is converted to an online-only open access journal. Cancer Genomics & Proteomics supports (a) the aims and the research projects of the INTERNATIONAL INSTITUTE OF ANTICANCER RESEARCH and (b) the organization of the INTERNATIONAL CONFERENCES OF ANTICANCER RESEARCH.