{"title":"视网膜母细胞瘤化疗后的羊膜增生去核术","authors":"Aparna Ramasubramanian, MD, Nisha S. Rehman, MD, Argudit Chauhan, BS, Aurora Rodriguez, BS, Amy Leverant, MD, Nishant Tiwari, MD","doi":"10.3928/01913913-20240307-01","DOIUrl":null,"url":null,"abstract":"<section><h3>Purpose:</h3><p>To describe amniotic membrane augmentation for enucleation after chemotherapy in retinoblastoma.</p></section><section><h3>Methods:</h3><p>This was a retrospective study of patients with retinoblastoma who underwent enucleation. The study also evaluated the utility of amniotic membrane grafting in enucleation after chemotherapy in eyes with retinoblastoma.</p></section><section><h3>Results:</h3><p>In this study, 110 eyes of 107 patients were analyzed, and 49 patients had previous systemic chemotherapy, 13 eyes had previous intra-arterial chemotherapy, and 7 eyes had external beam radiation. Amniotic graft was used in 8 eyes (5 following IAC, 2 following systemic chemotherapy, and 1 after both). After IAC, 3 of 7 eyes without amniotic graft had implant exposure compared to 0 of 6 eyes with amniotic graft (<i>P</i> = .05). Pathological examination of the conjunctiva after intra-arterial chemotherapy showed goblet cell hypoplasia that hinders wound healing.</p></section><section><h3>Conclusions:</h3><p>Amniotic membrane augmentation improves wound integrity in patients with retinoblastoma, especially following intra-arterial chemotherapy.</p><p><strong>[<i>J Pediatr Ophthalmol Strabismus</i>. 20XX;X(X):XXX–XXX.]</strong></p></section>","PeriodicalId":519537,"journal":{"name":"Journal of Pediatric Ophthalmology and Strabismus","volume":"12 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Amniotic Membrane Augmentation for Enucleation After Chemotherapy in Retinoblastoma\",\"authors\":\"Aparna Ramasubramanian, MD, Nisha S. Rehman, MD, Argudit Chauhan, BS, Aurora Rodriguez, BS, Amy Leverant, MD, Nishant Tiwari, MD\",\"doi\":\"10.3928/01913913-20240307-01\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<section><h3>Purpose:</h3><p>To describe amniotic membrane augmentation for enucleation after chemotherapy in retinoblastoma.</p></section><section><h3>Methods:</h3><p>This was a retrospective study of patients with retinoblastoma who underwent enucleation. The study also evaluated the utility of amniotic membrane grafting in enucleation after chemotherapy in eyes with retinoblastoma.</p></section><section><h3>Results:</h3><p>In this study, 110 eyes of 107 patients were analyzed, and 49 patients had previous systemic chemotherapy, 13 eyes had previous intra-arterial chemotherapy, and 7 eyes had external beam radiation. Amniotic graft was used in 8 eyes (5 following IAC, 2 following systemic chemotherapy, and 1 after both). After IAC, 3 of 7 eyes without amniotic graft had implant exposure compared to 0 of 6 eyes with amniotic graft (<i>P</i> = .05). Pathological examination of the conjunctiva after intra-arterial chemotherapy showed goblet cell hypoplasia that hinders wound healing.</p></section><section><h3>Conclusions:</h3><p>Amniotic membrane augmentation improves wound integrity in patients with retinoblastoma, especially following intra-arterial chemotherapy.</p><p><strong>[<i>J Pediatr Ophthalmol Strabismus</i>. 20XX;X(X):XXX–XXX.]</strong></p></section>\",\"PeriodicalId\":519537,\"journal\":{\"name\":\"Journal of Pediatric Ophthalmology and Strabismus\",\"volume\":\"12 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-04-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Pediatric Ophthalmology and Strabismus\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3928/01913913-20240307-01\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pediatric Ophthalmology and Strabismus","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3928/01913913-20240307-01","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Amniotic Membrane Augmentation for Enucleation After Chemotherapy in Retinoblastoma
Purpose:
To describe amniotic membrane augmentation for enucleation after chemotherapy in retinoblastoma.
Methods:
This was a retrospective study of patients with retinoblastoma who underwent enucleation. The study also evaluated the utility of amniotic membrane grafting in enucleation after chemotherapy in eyes with retinoblastoma.
Results:
In this study, 110 eyes of 107 patients were analyzed, and 49 patients had previous systemic chemotherapy, 13 eyes had previous intra-arterial chemotherapy, and 7 eyes had external beam radiation. Amniotic graft was used in 8 eyes (5 following IAC, 2 following systemic chemotherapy, and 1 after both). After IAC, 3 of 7 eyes without amniotic graft had implant exposure compared to 0 of 6 eyes with amniotic graft (P = .05). Pathological examination of the conjunctiva after intra-arterial chemotherapy showed goblet cell hypoplasia that hinders wound healing.
Conclusions:
Amniotic membrane augmentation improves wound integrity in patients with retinoblastoma, especially following intra-arterial chemotherapy.
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