腹膜透析患者腹腔液中 8- 羟基-2'-脱氧鸟苷水平与腹膜平衡试验、Kt/V、铁蛋白和白蛋白水平之间的相关性。

IF 0.8 4区医学 Q4 UROLOGY & NEPHROLOGY

Iranian journal of kidney diseases Pub Date : 2024-04-25 DOI:10.5254/fte08z03

Hadi Khanifar, Leila Mahmoodnia

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引用次数: 0

摘要

腹膜透析（PD）是晚期肾衰竭的一种有效治疗方式，可为患者提供很大程度的独立性。然而，由于腹膜退化导致透析充分性降低，腹膜透析的长期使用受到限制。使用现有方法评估接受腹膜透析的晚期肾衰竭患者的腹膜状况具有挑战性。因此，本研究旨在探讨腹膜透析患者腹腔溶液中 8- 羟基-2'-脱氧鸟苷（8OHDG）水平与腹膜平衡试验（PET）、透析充分性（Kt/V）、基础疾病、血清铁蛋白和白蛋白水平等各种因素之间的相关性。8OHDG 是 DNA 损伤导致氧化应激的敏感标记。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Correlation Between the 8-hydroxy-2'-deoxyguanosine Level in the Peritoneal Solution of Patients Undergoing Peritoneal Dialysis and the Peritoneal Equilibration Test, Kt/V, Ferritin, and Albumin Levels.

Peritoneal dialysis (PD) is an effective treatment modality for advanced kidney failure, offering patients a significant degree of independence. However, the long-term use of PD is limited due to the degeneration of the peritoneal membrane, resulting in reduced dialysis adequacy. Evaluating the peritoneal membrane condition in patients with advanced kidney failure who are undergoing PD is challenging with existing methods. Therefore, this study aimed to investigate the correlation between 8-hydroxy-2'-deoxyguanosine (8OHDG) levels in the peritoneal solution of patients undergoing PD and various factors, such as peritoneal equilibration test (PET), dialysis adequacy (Kt/V), underlying diseases, serum ferritin, and albumin levels. 8OHDG is a sensitive marker of oxidative stress caused by DNA damage.

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来源期刊

Iranian journal of kidney diseases UROLOGY & NEPHROLOGY-

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The Iranian Journal of Kidney Diseases (IJKD), a peer-reviewed journal in English, is the official publication of the Iranian Society of Nephrology. The aim of the IJKD is the worldwide reflection of the knowledge produced by the scientists and clinicians in nephrology. Published quarterly, the IJKD provides a new platform for advancement of the field. The journal’s objective is to serve as a focal point for debates and exchange of knowledge and experience among researchers in a global context. Original papers, case reports, and invited reviews on all aspects of the kidney diseases, hypertension, dialysis, and transplantation will be covered by the IJKD. Research on the basic science, clinical practice, and socio-economics of renal health are all welcomed by the editors of the journal.