用于控制心房颤动的神经调制。

IF 3 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Seil Oh
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引用次数: 0

摘要

触发和功能基质与自主神经系统的张力有关,与非阵发性房颤相比,自主神经在阵发性房颤中的作用更为显著。我们有多种神经调控方案来帮助管理房颤患者。神经调节的目标可分为传出和传入途径。在传出方面,阻滞是一种直观的方法。然而,由于手术的完整性和再神经支配问题,永久阻滞很难实现。对于心脏手术后的房颤,暂时性阻滞(如向神经节丛注射肉毒杆菌毒素)是一个可行的选择。低水平的阈下刺激也可以预防房颤,但手术的侵入性是普遍使用的障碍。在传入方面,阻断也是一种选择。目前正在研究各种肾脏神经支配方法。听觉迷走神经刺激是具有代表性的低水平传入刺激方法之一。这种技术无创且易于应用,因此如果其疗效得到证实,将有可能得到广泛应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neuromodulation for Atrial Fibrillation Control.
Trigger and functional substrate are related to the tone of autonomic nervous system, and the role of the autonomic nerve is more significant in paroxysmal atrial fibrillation (AF) compared to non-paroxysmal AF. We have several options for neuromodulation to help to manage patients with AF. Neuromodulation targets can be divided into efferent and afferent pathways. On the efferent side, block would be an intuitive approach. However, permanent block is hard to achieve due to completeness of the procedure and reinnervation issues. Temporary block such as botulinum toxin injection into ganglionated plexi would be a possible option for post-cardiac surgery AF. Low-level subthreshold stimulation could also prevent AF, but the invasiveness of the procedure is the barrier for the general use. On the afferent side, block is also an option. Various renal denervation approaches are currently under investigation. Auditory vagus nerve stimulation is one of the representative low-level afferent stimulation methods. This technique is noninvasive and easy to apply, so it has the potential to be widely utilized if its efficacy is confirmed.
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来源期刊
Korean Circulation Journal
Korean Circulation Journal CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
4.90
自引率
17.20%
发文量
103
期刊介绍: Korean Circulation Journal is the official journal of the Korean Society of Cardiology, the Korean Pediatric Heart Society, the Korean Society of Interventional Cardiology, and the Korean Society of Heart Failure. Abbreviated title is ''Korean Circ J''. Korean Circulation Journal, established in 1971, is a professional, peer-reviewed journal covering all aspects of cardiovascular medicine, including original articles of basic research and clinical findings, review articles, editorials, images in cardiovascular medicine, and letters to the editor. Korean Circulation Journal is published monthly in English and publishes scientific and state-of-the-art clinical articles aimed at improving human health in general and contributing to the treatment and prevention of cardiovascular diseases in particular. The journal is published on the official website (https://e-kcj.org). It is indexed in PubMed, PubMed Central, Science Citation Index Expanded (SCIE, Web of Science), Scopus, EMBASE, Chemical Abstracts Service (CAS), Google Scholar, KoreaMed, KoreaMed Synapse and KoMCI, and easily available to wide international researchers
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