Iacopo Petrini , Rossella Bruno , Iosè Di Stefano , Vittorio Aprile , Stylianos Korasidis , Eleonora Pardini , Antonio Chella , Greta Alì
{"title":"一名表皮生长因子受体基因突变（p.R776H）患者患有多种肺癌，并携带不同的体细胞表皮生长因子受体基因突变。","authors":"Iacopo Petrini , Rossella Bruno , Iosè Di Stefano , Vittorio Aprile , Stylianos Korasidis , Eleonora Pardini , Antonio Chella , Greta Alì","doi":"10.1016/j.cllc.2024.04.007","DOIUrl":null,"url":null,"abstract":"<div><p></p><ul><li><span>•</span><span><p>There are not standard guidelines for the selection and treatment of patients with synchronous multiple nodules with ground glass/lepidic features.</p></span></li><li><span>•</span><span><p>The presence of different <em>EGFR</em> mutations in the various resected nodules with ground glass/lepidic features suggests the existence of multifocal primary tumors.</p></span></li><li><span>•</span><span><p>The results suggest the possibility that a germline mutation in an oncogene could facilitate the development of a tumor with additional mutations in the same oncogene.</p></span></li></ul></div>","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1525730424000500/pdfft?md5=3fc1e0067224b967458ed5d35f33c257&pid=1-s2.0-S1525730424000500-main.pdf","citationCount":"0","resultStr":"{\"title\":\"A patient with a Germline (p.R776H) EGFR Mutation With Multiple Lung Cancers Harboring Different Somatic EGFR Mutations\",\"authors\":\"Iacopo Petrini , Rossella Bruno , Iosè Di Stefano , Vittorio Aprile , Stylianos Korasidis , Eleonora Pardini , Antonio Chella , Greta Alì\",\"doi\":\"10.1016/j.cllc.2024.04.007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p></p><ul><li><span>•</span><span><p>There are not standard guidelines for the selection and treatment of patients with synchronous multiple nodules with ground glass/lepidic features.</p></span></li><li><span>•</span><span><p>The presence of different <em>EGFR</em> mutations in the various resected nodules with ground glass/lepidic features suggests the existence of multifocal primary tumors.</p></span></li><li><span>•</span><span><p>The results suggest the possibility that a germline mutation in an oncogene could facilitate the development of a tumor with additional mutations in the same oncogene.</p></span></li></ul></div>\",\"PeriodicalId\":3,\"journal\":{\"name\":\"ACS Applied Electronic Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2024-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1525730424000500/pdfft?md5=3fc1e0067224b967458ed5d35f33c257&pid=1-s2.0-S1525730424000500-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Electronic Materials\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1525730424000500\",\"RegionNum\":3,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, ELECTRICAL & ELECTRONIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Electronic Materials","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1525730424000500","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}
A patient with a Germline (p.R776H) EGFR Mutation With Multiple Lung Cancers Harboring Different Somatic EGFR Mutations
•
There are not standard guidelines for the selection and treatment of patients with synchronous multiple nodules with ground glass/lepidic features.
•
The presence of different EGFR mutations in the various resected nodules with ground glass/lepidic features suggests the existence of multifocal primary tumors.
•
The results suggest the possibility that a germline mutation in an oncogene could facilitate the development of a tumor with additional mutations in the same oncogene.
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