小儿肾移植：癌症与癌症风险

IF 2.8 3区医学 Q2 UROLOGY & NEPHROLOGY

Seminars in nephrology Pub Date : 2024-01-01 DOI:10.1016/j.semnephrol.2024.151501

Kaitlyn E. Order MD, Nancy M. Rodig MD

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引用次数: 0

摘要

终末期肾病（ESKD）患儿一生都要面对复杂的医疗护理，在维持慢性透析和肾移植之间交替进行。肾移植已成为治疗儿童终末期肾病的最佳方法，并在生活质量和存活率方面具有重要优势。虽然移植是首选疗法，但 ESKD 儿童终生暴露于免疫抑制与发病率增加有关，包括癌症风险增加。小儿肾移植后，儿童期或青年期发生的癌症可分为两大类：移植后淋巴增生性疾病和非淋巴增生性实体瘤。本综述概述了这一人群的癌症发病率、类型、结果和预防策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Pediatric Kidney Transplantation: Cancer and Cancer Risk

Children with end-stage kidney disease (ESKD) face a lifetime of complex medical care, alternating between maintenance chronic dialysis and kidney transplantation. Kidney transplantation has emerged as the optimal treatment of ESKD for children and provides important quality of life and survival advantages. Although transplantation is the preferred therapy, lifetime exposure to immunosuppression among children with ESKD is associated with increased morbidity, including an increased risk of cancer. Following pediatric kidney transplantation, cancer events occurring during childhood or young adulthood can be divided into two broad categories: post-transplant lymphoproliferative disorders and non-lymphoproliferative solid tumors. This review provides an overview of cancer incidence, types, outcomes, and preventive strategies in this population.

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来源期刊

Seminars in nephrology 医学-泌尿学与肾脏学

CiteScore

5.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Seminars in Nephrology is a timely source for the publication of new concepts and research findings relevant to the clinical practice of nephrology. Each issue is an organized compendium of practical information that serves as a lasting reference for nephrologists, internists and physicians in training.