基于无意义 RNA 降解的新型四基因特征预测肝细胞癌预后：生物信息学分析和功能验证

IF 4.2 3区医学 Q2 ONCOLOGY

Journal of Hepatocellular Carcinoma Pub Date : 2024-04-01 DOI:10.2147/jhc.s450711

Jiaxin Zhao, Cheng Wang, Liang Zhao, Huiying Zhou, Rui Wu, Tao Zhang, Jiawei Ding, Junjie Zhou, Huilin Zheng, Lei Zhang, Tianci Kong, Jie Zhou, Zhenhua Hu

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引用次数: 0

摘要

目的：有义基因介导的 RNA 降解（NMD）是选择性降解异常 mRNA 的监控途径，与癌症进展有关。它作为侵袭性肝细胞癌（HCC）预测指标的潜力尚不明确。在此，我们提出了一种创新的 NMD 风险模型，用于预测 HCC 预后

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A Novel Four-Gene Signature Based on Nonsense-Mediated RNA Decay for Predicting Prognosis in Hepatocellular Carcinoma: Bioinformatics Analysis and Functional Validation

Purpose: Nonsense-mediated RNA decay (NMD), a surveillance pathway for selective degradation of aberrant mRNAs, is associated with cancer progression. Its potential as a predictor for aggressive hepatocellular carcinoma (HCC) is unclear. Here, we present an innovative NMD risk model for predicting HCC prognosis

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来源期刊

Journal of Hepatocellular Carcinoma ONCOLOGY-

CiteScore

0.50

自引率

2.40%

发文量

108

审稿时长

16 weeks