在糖尿病和其他代谢综合征相关疾病动物模型中使用麦角苷或玛咖的体内研究--范围综述

Najwa Hanim Othman, H. R. Ismawi, Maizura Mohd Zainudin, Azliana Abd. Fuaat
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引用次数: 0

摘要

Lepidium meyenii 或 Maca 是一种秘鲁植物,属于十字花科。玛咖因其生物活性化合物的多样性而具有多种保健功效。研究表明,玛咖具有多种功效,包括治疗糖尿病(DM)和其他代谢综合征相关疾病。本综述旨在揭示玛咖以前发现的潜在抗糖尿病作用,以及在体内动物模型中治疗与代谢综合征有关的其他疾病的潜力。我们采用 Arksey 和 O'Malley 的方案对文献进行了范围界定。该方案的核心是确定研究问题、识别和选择相关研究、绘制数据图表以及整理、总结和报告研究结果。使用 Semantic Scholar、Scopus、PubMed Central 和 ScienceDirect 进行了搜索。六项研究被纳入综述。这些研究的目的、方法和研究结果的细节各不相同。它们包括在不同类型的动物模型中服用玛咖,以及玛咖对几种生化参数的影响。本综述提供的基本科学证据支持玛咖在糖尿病和其他代谢综合征相关疾病动物模型中的抗糖尿病特性。然而,报告的稀缺性表明今后需要进行更严格的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
In Vivo Studies of Lepidium meyenii or Maca in Animal Models of Diabetes Mellitus and Other Metabolic Syndrome-Related Diseases- A Scoping Review
Lepidium meyenii or Maca is a Peruvian plant that belongs to the Brassicaceae family. Maca has various attributed health benefits due to the diversity of its bioactive compounds. Studies reveal that Maca is effective for many purposes including in the treatment of diabetes mellitus (DM) and other metabolic syndrome-related diseases. This review aims to uncover previously identified underlying anti-diabetic effects of Maca as well as its potential in the treatment of other conditions linked to metabolic syndrome in animal models in vivo. A scoping review of the literature was conducted using a protocol by Arksey and O’Malley. The protocol centred on the identification of research questions, identification and selection of relevant studies, data charting and collating, summarizing, and reporting the findings. Searches were conducted using Semantic Scholar, Scopus, PubMed Central, and ScienceDirect. Six studies were included in the review. The studies varied in terms of purpose, methodology, and detail of findings. They include the administration of Maca in different types of animal models and its effect on several biochemical parameters. There is fundamental scientific evidence from this review that supports the anti-diabetic properties of Maca in animal models of DM and other metabolic syndrome-related diseases. However, the scarcity of reports indicates the need for more rigorous studies in the future.
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