揭开纳米生物融合的神秘面纱:量子点与蛋白质相互作用、其影响和应用的系统综述

IF 3.3 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Jagriti Gupta, Pradeep Kumar Vaid, Eepsita Priyadarshini, Paulraj Rajamani
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引用次数: 0

摘要

量子点(QDs)是一种半导体纳米晶体(2-10 纳米),由于量子约束效应而具有独特的光学和电子特性。它们具有高光稳定性、窄发射光谱、宽吸收光谱和高量子产率,因此在各种应用中用途广泛。由于其表面具有高活性,QDs 在使用、生产或无意中释放到环境中时,可与生物分子结合。这篇系统性综述深入探讨了 QDs 与蛋白质之间错综复杂的关系,研究了它们之间影响其理化性质、酶活性、配体结合亲和力和稳定性的相互作用。研究利用了 PubMed、WOS 和 Proquest 等电子数据库,并使用相关关键词对 2013 年至 2023 年的文献进行了人工查阅,以确定合适的文献。在对标题和摘要进行筛选后,只有符合纳入标准的文章才会被选中进行全文阅读。本系统性综述从 395 篇文章中筛选出 125 篇符合纳入标准的文章,并将其分为五大主题,涵盖了 QDs 与蛋白质相互作用的各种机制,包括吸附、共价结合以及 QDs 的物理化学特性。通过对现有文献的细致分析,该报告揭示了相互作用的复杂本质、对纳米材料和生物实体的重大影响,以及利用特异性和非特异性相互作用在各个领域进行协同应用的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Nano-bio convergence unveiled: Systematic review on quantum dots-protein interaction, their implications, and applications

Nano-bio convergence unveiled: Systematic review on quantum dots-protein interaction, their implications, and applications

Quantum dots (QDs) are semiconductor nanocrystals (2–10 nm) with unique optical and electronic properties due to quantum confinement effects. They offer high photostability, narrow emission spectra, broad absorption spectrum, and high quantum yields, making them versatile in various applications. Due to their highly reactive surfaces, QDs can conjugate with biomolecules while being used, produced, or unintentionally released into the environment. This systematic review delves into intricate relationship between QDs and proteins, examining their interactions that influence their physicochemical properties, enzymatic activity, ligand binding affinity, and stability. The research utilized electronic databases like PubMed, WOS, and Proquest, along with manual reviews from 2013 to 2023 using relevant keywords, to identify suitable literature. After screening titles and abstracts, only articles meeting inclusion criteria were selected for full text readings. This systematic review of 395 articles identifies 125 articles meeting the inclusion criteria, categorized into five overarching themes, encompassing various mechanisms of QDs and proteins interactions, including adsorption to covalent binding, contingent on physicochemical properties of QDs. Through a meticulous analysis of existing literature, it unravels intricate nature of interaction, significant influence on nanomaterials and biological entities, and potential for synergistic applications harnessing both specific and nonspecific interactions across various fields.

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来源期刊
Biophysical chemistry
Biophysical chemistry 生物-生化与分子生物学
CiteScore
6.10
自引率
10.50%
发文量
121
审稿时长
20 days
期刊介绍: Biophysical Chemistry publishes original work and reviews in the areas of chemistry and physics directly impacting biological phenomena. Quantitative analysis of the properties of biological macromolecules, biologically active molecules, macromolecular assemblies and cell components in terms of kinetics, thermodynamics, spatio-temporal organization, NMR and X-ray structural biology, as well as single-molecule detection represent a major focus of the journal. Theoretical and computational treatments of biomacromolecular systems, macromolecular interactions, regulatory control and systems biology are also of interest to the journal.
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