免疫性血小板减少症的病理生理学、临床表现和诊断:历史视角下的背景分析

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Daniel Martínez-Carballeira, Ángel Bernardo, Alberto Caro, Inmaculada Soto, Laura Gutiérrez
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引用次数: 0

摘要

免疫性血小板减少症(ITP)是一种自身免疫性疾病,其特点是血小板数量个别减少,出血风险增加。其发病机制复杂,影响免疫系统的多个组成部分,既可导致血小板外周破坏,也可导致中枢巨核细胞生成和骨髓中血小板生成受损。在此,我们将从历史的视角和对这一实体不断积累的知识的首次引用出发,介绍有关 ITP 的病理生理学、术语、流行病学、临床表现、诊断和预后的现有知识。我们强调有必要更好地了解 ITP,以便为 ITP 患者提供个性化的治疗方案,改善疾病的预后,降低反跳的发生率或频率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pathophysiology, Clinical Manifestations and Diagnosis of Immune Thrombocytopenia: Contextualization from a Historical Perspective
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by an isolated decrease in the platelet count and an increased risk of bleeding. The pathogenesis is complex, affecting multiple components of the immune system and causing both peripheral destruction of platelets and impaired central megakaryopoiesis and platelet production in the bone marrow. Here, we intend to contextualize the current knowledge on the pathophysiology, terminology, epidemiology, clinical manifestations, diagnosis, and prognosis of ITP from a historical perspective and the first references to the never-stopping garnering of knowledge about this entity. We highlight the necessity to better understand ITP in order to be able to provide ITP patients with personalized treatment options, improving disease prognosis and reducing the incidence or frequency of refractoriness.
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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