Focal segmental glomerulosclerosis

Some cases of FSGS will resolve with treatment with oral steroids (drugs such as prednisone). Often this does not work and other agents are used including chemotherapy drugs such as cyclophosphamide and immunosuppressant drugs such as cyclosporine (NeoralTM). Control of high blood pressure is also very important in preventing kidney failure. Drugs such as ACE inhibitors or others may be used to control this complication. In about half of all patients, none of these treatments work to cure the FSGS. In this case, blood pressure medications are very important to keep the kidneys working as long as possible. Other drugs may be needed to control swelling and the fat content of the blood.