{"title":"TSH 抑制疗法在分化型甲状腺癌患者术后管理中的作用","authors":"Xudong Gao, Bo Zhao, Ya Su, Shenglin He","doi":"10.26689/par.v8i2.6295","DOIUrl":null,"url":null,"abstract":"Objective: To investigate the effect of TSH inhibition therapy in the postoperative management of patients with differentiated thyroid cancer. Methods: Seventy patients diagnosed with differentiated thyroid cancer were selected for the study. TSH inhibition therapy was administered to the research group, while thyroxine replacement therapy was provided to the control group during the postoperative management phase. This allowed for a comparative analysis between the two groups. Results: In comparison with the control group, the research group exhibited significant decreases in serum TSH, T3, and T4 levels after treatment, while FT4 and FT3 levels significantly increased (P < 0.05). Additionally, significant decreases in Tg, VEGF, TSGF, CD44V6, and sIL-2R levels were observed in the research group after treatment (P < 0.05). No significant differences were found in pre-treatment thyroid function between the two groups (P > 0.05). Conclusion: The application of TSH inhibition therapy in the postoperative management of patients with differentiated thyroid cancer demonstrates promising outcomes.","PeriodicalId":20511,"journal":{"name":"Proceedings of Anticancer Research","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Role of TSH Inhibition Therapy in the Postoperative Management of Patients with Differentiated Thyroid Cancer\",\"authors\":\"Xudong Gao, Bo Zhao, Ya Su, Shenglin He\",\"doi\":\"10.26689/par.v8i2.6295\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective: To investigate the effect of TSH inhibition therapy in the postoperative management of patients with differentiated thyroid cancer. Methods: Seventy patients diagnosed with differentiated thyroid cancer were selected for the study. TSH inhibition therapy was administered to the research group, while thyroxine replacement therapy was provided to the control group during the postoperative management phase. This allowed for a comparative analysis between the two groups. Results: In comparison with the control group, the research group exhibited significant decreases in serum TSH, T3, and T4 levels after treatment, while FT4 and FT3 levels significantly increased (P < 0.05). Additionally, significant decreases in Tg, VEGF, TSGF, CD44V6, and sIL-2R levels were observed in the research group after treatment (P < 0.05). No significant differences were found in pre-treatment thyroid function between the two groups (P > 0.05). Conclusion: The application of TSH inhibition therapy in the postoperative management of patients with differentiated thyroid cancer demonstrates promising outcomes.\",\"PeriodicalId\":20511,\"journal\":{\"name\":\"Proceedings of Anticancer Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-04-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Proceedings of Anticancer Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.26689/par.v8i2.6295\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of Anticancer Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.26689/par.v8i2.6295","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Role of TSH Inhibition Therapy in the Postoperative Management of Patients with Differentiated Thyroid Cancer
Objective: To investigate the effect of TSH inhibition therapy in the postoperative management of patients with differentiated thyroid cancer. Methods: Seventy patients diagnosed with differentiated thyroid cancer were selected for the study. TSH inhibition therapy was administered to the research group, while thyroxine replacement therapy was provided to the control group during the postoperative management phase. This allowed for a comparative analysis between the two groups. Results: In comparison with the control group, the research group exhibited significant decreases in serum TSH, T3, and T4 levels after treatment, while FT4 and FT3 levels significantly increased (P < 0.05). Additionally, significant decreases in Tg, VEGF, TSGF, CD44V6, and sIL-2R levels were observed in the research group after treatment (P < 0.05). No significant differences were found in pre-treatment thyroid function between the two groups (P > 0.05). Conclusion: The application of TSH inhibition therapy in the postoperative management of patients with differentiated thyroid cancer demonstrates promising outcomes.
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