基于经皮迷走神经电刺激的耐药性癫痫治疗平台的首批成果

R. Gonzalez-Fernandez, Vicente Rio-Vazquez, J. G. Perez-Blanco, E. Velarde-Reyes, Liana Portela-Hernandez, Aisel Santos-Santos, Joel Gutiérrez-Gil, J. Hernandez-Caceres
{"title":"基于经皮迷走神经电刺激的耐药性癫痫治疗平台的首批成果","authors":"R. Gonzalez-Fernandez, Vicente Rio-Vazquez, J. G. Perez-Blanco, E. Velarde-Reyes, Liana Portela-Hernandez, Aisel Santos-Santos, Joel Gutiérrez-Gil, J. Hernandez-Caceres","doi":"10.37349/en.2024.00041","DOIUrl":null,"url":null,"abstract":"Aim: The aim of this paper is to discuss the main features and first outcomes of a therapeutic platform proposed to implement a public health therapeutic service for patients suffering refractory epilepsy.\nMethods: The proposal is a three-layer system composed by a new portable therapy device and two software applications. The therapy is transcutaneous electrical vagus nerve stimulation, known as tVNS. The primary layer is composed of tVNS devices, configured for each patient according to the instructions provided by the specialists. The middle layer is named “hospital data collector” (HDC), its main tasks are the patient enrollment, the device setup, and the database maintenance to store therapeutic parameters and session events together with the information cited previously. Each hospital center runs a HDC that is connected to a cloud application named “system cloud application (SCA)” which concentrates all the data supplied by the HDCs. Artificial intelligence methods are integrated in the SCA to predict the treatment effectiveness for every new patient based on the accumulated knowledge from the enrolled previously.\nResults: A version of the proposed system is running at the Institute of Neurology and Neurosurgery. The sensitivity of the therapeutic device with the proposed treatment protocol reaches 83.33% in the 18-patient pilot trial carried out.\nConclusions: The proposed approach seems a useful therapeutic tool based on the pilot trial outcomes. The developed device is comfortable and suitable for the intended use. The proposed system has created the essential conditions to feed and grow a knowledge, a basic element to predict the treatment effectiveness for each new patient. It is a promising option for a refractory epilepsy therapy service.","PeriodicalId":73001,"journal":{"name":"Exploration of neuroscience","volume":"6 10","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"First outcomes of a therapeutic platform for drug resistant epilepsy based on transcutaneous electrical vagus nerve stimulation\",\"authors\":\"R. Gonzalez-Fernandez, Vicente Rio-Vazquez, J. G. Perez-Blanco, E. Velarde-Reyes, Liana Portela-Hernandez, Aisel Santos-Santos, Joel Gutiérrez-Gil, J. Hernandez-Caceres\",\"doi\":\"10.37349/en.2024.00041\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Aim: The aim of this paper is to discuss the main features and first outcomes of a therapeutic platform proposed to implement a public health therapeutic service for patients suffering refractory epilepsy.\\nMethods: The proposal is a three-layer system composed by a new portable therapy device and two software applications. The therapy is transcutaneous electrical vagus nerve stimulation, known as tVNS. The primary layer is composed of tVNS devices, configured for each patient according to the instructions provided by the specialists. The middle layer is named “hospital data collector” (HDC), its main tasks are the patient enrollment, the device setup, and the database maintenance to store therapeutic parameters and session events together with the information cited previously. Each hospital center runs a HDC that is connected to a cloud application named “system cloud application (SCA)” which concentrates all the data supplied by the HDCs. Artificial intelligence methods are integrated in the SCA to predict the treatment effectiveness for every new patient based on the accumulated knowledge from the enrolled previously.\\nResults: A version of the proposed system is running at the Institute of Neurology and Neurosurgery. The sensitivity of the therapeutic device with the proposed treatment protocol reaches 83.33% in the 18-patient pilot trial carried out.\\nConclusions: The proposed approach seems a useful therapeutic tool based on the pilot trial outcomes. The developed device is comfortable and suitable for the intended use. The proposed system has created the essential conditions to feed and grow a knowledge, a basic element to predict the treatment effectiveness for each new patient. It is a promising option for a refractory epilepsy therapy service.\",\"PeriodicalId\":73001,\"journal\":{\"name\":\"Exploration of neuroscience\",\"volume\":\"6 10\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-04-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Exploration of neuroscience\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.37349/en.2024.00041\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Exploration of neuroscience","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.37349/en.2024.00041","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

目的:本文旨在讨论为难治性癫痫患者提供公共卫生治疗服务的治疗平台的主要特点和初步成果:该建议是一个由新型便携式治疗设备和两个应用软件组成的三层系统。该疗法是经皮迷走神经电刺激疗法(tVNS)。第一层由 tVNS 设备组成,根据专家提供的说明为每位患者进行配置。中间层被命名为 "医院数据采集器"(HDC),其主要任务是患者注册、设备设置和数据库维护,以存储治疗参数和疗程事件以及之前引用的信息。每个医院中心都运行一个 HDC,该 HDC 与一个名为 "系统云应用程序(SCA)"的云应用程序相连,后者集中了 HDC 提供的所有数据。系统云应用(SCA)中集成了人工智能方法,可根据之前入院病人积累的知识预测每位新病人的治疗效果:结果:拟议系统的一个版本正在神经学和神经外科研究所运行。在对 18 名患者进行的试点试验中,采用建议治疗方案的治疗设备的灵敏度达到 83.33%:结论:根据试点试验结果,建议的方法似乎是一种有用的治疗工具。结论:根据试点试验的结果,所建议的方法似乎是一种有用的治疗工具。所开发的设备使用舒适,适合预期用途。拟议的系统为知识的积累和增长创造了必要条件,而知识是预测每个新病人治疗效果的基本要素。对于难治性癫痫治疗服务来说,这是一个很有前景的选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
First outcomes of a therapeutic platform for drug resistant epilepsy based on transcutaneous electrical vagus nerve stimulation
Aim: The aim of this paper is to discuss the main features and first outcomes of a therapeutic platform proposed to implement a public health therapeutic service for patients suffering refractory epilepsy. Methods: The proposal is a three-layer system composed by a new portable therapy device and two software applications. The therapy is transcutaneous electrical vagus nerve stimulation, known as tVNS. The primary layer is composed of tVNS devices, configured for each patient according to the instructions provided by the specialists. The middle layer is named “hospital data collector” (HDC), its main tasks are the patient enrollment, the device setup, and the database maintenance to store therapeutic parameters and session events together with the information cited previously. Each hospital center runs a HDC that is connected to a cloud application named “system cloud application (SCA)” which concentrates all the data supplied by the HDCs. Artificial intelligence methods are integrated in the SCA to predict the treatment effectiveness for every new patient based on the accumulated knowledge from the enrolled previously. Results: A version of the proposed system is running at the Institute of Neurology and Neurosurgery. The sensitivity of the therapeutic device with the proposed treatment protocol reaches 83.33% in the 18-patient pilot trial carried out. Conclusions: The proposed approach seems a useful therapeutic tool based on the pilot trial outcomes. The developed device is comfortable and suitable for the intended use. The proposed system has created the essential conditions to feed and grow a knowledge, a basic element to predict the treatment effectiveness for each new patient. It is a promising option for a refractory epilepsy therapy service.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信