将 ADAMTS 的前胶原 N-肽酶基因家族作为与预后、肿瘤免疫微环境、信号通路和药物敏感性相关联的新型生物标记物的多指标泛癌分析

IF 3.1 4区生物学 Q2 Immunology and Microbiology

Frontiers in Bioscience-Landmark Pub Date : 2024-04-12 DOI:10.31083/j.fbl2904151

Yuxing Chen, Chaoyu Xiao, Qingxin Fan, Ye Zhang, Qiu Huang, Yunsheng Ou

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引用次数: 0

摘要

背景：金属蛋白酶诱导的细胞外基质（ECM）建模是肿瘤进展的一个重要特征。以往的研究主要集中于两类金属蛋白酶在肿瘤中的功能：基质金属蛋白酶（MMPs）和崩解蛋白与金属蛋白酶（ADAMs）。另一组重要的金属蛋白酶：具有凝血酶蛋白基序的 ADAMs（ADAMTS）的作用仍不清楚。本研究旨在对 ADAMTS 的胶原 N-肽酶亚群（PNPSA）进行泛癌分析。方法：我们系统分析了ADAMTS亚群的表达状况、基因组变异、预后价值以及对癌症的影响。

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Multi-Omics Pan-Cancer Analysis of Procollagen N-Propeptidase Gene Family of ADAMTS as Novel Biomarkers to Associate with Prognosis, Tumor Immune Microenvironment, Signaling Pathways, and Drug Sensitivities

Background : The extracellular matrix (ECM) modeling induced by the metalloproteinases is a vital characteristic for tumor progression. Previous studies mainly focus on the functions of two subgroups of metalloproteinases: matrix metalloproteinases (MMPs) and a disintegrin and metalloproteases (ADAMs) in tumors. The roles of another important group: the ADAMs with thrombospondin motifs (ADAMTS) remain unclear. This study aimed to perform a pan-cancer analysis of procollagen N-propeptidase subgroup of ADAMTS (PNPSA). Methods : We systematically analyzed expression landscape, genomic variations, prognostic value

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来源期刊

Frontiers in Bioscience-Landmark 生物-生化与分子生物学

CiteScore

3.40

自引率

3.20%

发文量

301

审稿时长

3 months

期刊介绍： FBL is an international peer-reviewed open access journal of biological and medical science. FBL publishes state of the art advances in any discipline in the area of biology and medicine, including biochemistry and molecular biology, parasitology, virology, immunology, epidemiology, microbiology, entomology, botany, agronomy, as well as basic medicine, preventive medicine, bioinformatics and other related topics.