骨髓母细胞瘤中 BRAF V600E 免疫表达的频率:拉丁美洲 86 例病例的多机构分析及文献综述。

IF 2.2 3区 医学
F-M Silveira, L-F Schuch, V. Pereira-Prado, E. Sicco, O. Almeda-Ojeda, N. Molina-Frechero, M-L Paparella, M. Villarroel-Dorrego, M. Hernadez, R. Bologna-Molina
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引用次数: 0

摘要

背景牙源性肿瘤发生的起因通常涉及 MAP 激酶通路的激活,其中 BRAF V600E 突变起着关键作用。本研究旨在调查拉丁美洲四个中心确诊的牙母细胞瘤中 BRAF V600E 免疫反应的频率,并将这一发现与所分析病例的组织学类型和亚型相关联。结果65/86 个病例(75.6%)检测到抗 BRAF V600E 抗体阳性。在 38/56 例(67.9%)传统性成釉细胞瘤和 27/30 例(90.0%)单囊性成釉细胞瘤中,BRAF V600E 均呈阳性。将单囊性绒母细胞瘤与传统绒母细胞瘤进行比较,发现BRAF V600E阳性率在统计学上存在显著差异(P=0.03)。在比较组织学变异时,常规磨骨母细胞瘤和单囊性磨骨母细胞瘤的 BRAF V600E 阳性率无统计学差异。BRAF V600E免疫反应的普遍性可能表明,利用BRAF靶向疗法治疗具有这种突变的骨髓母细胞瘤是可行的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Frequency of BRAF V600E immunoexpression in ameloblastomas: a multi-institutional analysis of 86 cases in Latin America and comprehensive review of the literature.
BACKGROUND The initiation of odontogenic tumorigenesis often involves the activation of the MAP-kinase pathway, with a pivotal role played by the BRAF V600E mutation. This study aimed to investigate the frequency of BRAF V600E immunoexpresion in ameloblastomas diagnosed in four Latin American centers and correlate this finding with the histological types and subtypes of the analyzed cases. MATERIAL AND METHODS A total of 86 samples of ameloblastomas were examined for immunohistochemistry using anti-BRAF V600E antibody. The histopathological features of each case were analyzed. RESULTS  Positivity for anti-BRAF V600E antibody was detected in 65/86 cases (75.6%). BRAF V600E was positive in 38/56 cases (67.9%) of conventional ameloblastomas and in 27/30 cases (90.0%) of unicystic ameloblastomas. A statistically significant difference in BRAF V600E positivity was observed when comparing unicystic ameloblastomas to conventional ameloblastomas (p=0.03). No statistically significant difference in BRAF V600E positivity was observed when comparing histological variants, both for conventional ameloblastomas and unicystic ameloblastomas. CONCLUSIONS This study highlights a high frequency of BRAF V600E immunoreactivity in ameloblastomas among Latin American cases. The prevalence of the BRAF V600E immunoexpresion may suggest the feasibility of utilizing BRAF-targeted therapy for ameloblastomas with this mutation.
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来源期刊
CiteScore
4.50
自引率
0.00%
发文量
52
期刊介绍: 1. Oral Medicine and Pathology: Clinicopathological as well as medical or surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, as well as orofacial neurological disorders, and systemic conditions with an impact on the oral cavity. 2. Oral Surgery: Surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, teeth, implants, oral surgical procedures. Surgical management of diseases affecting head and neck areas. 3. Medically compromised patients in Dentistry: Articles discussing medical problems in Odontology will also be included, with a special focus on the clinico-odontological management of medically compromised patients, and considerations regarding high-risk or disabled patients. 4. Implantology 5. Periodontology
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