比较 Beraksurf 和 Curosurf 外源表面活性物质治疗早产新生儿呼吸窘迫综合征的效果:伊朗西部的一项双盲随机研究。

IF 1.3 Q3 PEDIATRICS
F. Eghbalian, B. Basiri, Behnaz Hatami, Narges Mohammadi Parsa, E. Jenabi
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引用次数: 0

摘要

背景迄今为止,很少有研究比较 Curosurf 和 Beraksurf 外源性表面活性物质治疗早产新生儿呼吸窘迫综合征(RDS)的效果。本临床试验针对伊朗西部哈马丹市两所大学专科医院 NICU 部门的 140 名早产 RDS 新生儿。一组使用伊朗生产的表面活性物质 Beraksurf,另一组使用意大利生产的表面活性物质 Curosurf。最后,完成了两组的核对表。结果两组使用 Beracsurf 和 Curosurf 表面活性剂的新生儿在母体使用皮质类固醇的频率分布、对治疗的反应和再次插管的需求、相关疾病和死亡率的比较未显示出显著差异(P 分别为 0.962、0.763、0.725 和 0.149)。此外,注射 Beracsurf 和 Curosurf 表面活性剂的两组新生儿需要呼吸支持的平均天数、无需呼吸支持的天数和住院天数的比较也未显示出显著差异(P 分别为 0.910、0.725 和 0.898)。此外,两组注射 Beracsurf 和 Curosurf 表面活性剂的新生儿开始进食的时间和达到最大进食量的时间比较也未显示出显著差异(P 分别为 0.881 和 0.903)。结论基于 Beracsurf 和 Curosurf 表面活性剂在早产新生儿 RDS 的治疗结果上没有显示出显著差异这一事实,建议使用伊朗产的 Beracsurf 表面活性剂治疗这些新生儿,因为与 Curosurf 相比,Beracsurf 具有成本效益和可用性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of the Effectiveness of Beraksurf and Curosurf Exogenous Surfactants in the Treatment of Respiratory Distress Syndrome in Preterm Neonates: A Double-blind Randomized Study in the West of Iran.
BACKGROUND To date, few studies have compared the effectiveness of exogenous surfactant therapy with Curosurf and Beraksurf in the treatment of respiratory distress syndrome (RDS) in preterm neonates. OBJECTIVE Since surfactant has a significant impact on the treatment of neonates with RDS, this study was conducted to introduce a more effective method for treating preterm neonates with RDS. METHODS The present clinical trial was conducted on 140 preterm neonates with RDS in the NICU department of two specialized university hospitals in Hamadan, western Iran. In one group, we used the Iranian-made surfactant Beraksurf, and in another group, we used the Italian-made surfactant Curosurf. In the end, the checklist for the two groups was completed. Data analysis was performed using SPSS version 22, and a significance level of 5% was considered for all tests. RESULTS The comparison of the frequency distribution of maternal corticosteroid administration, response to treatment and need for re-intubation, associated disorders, and mortality among neonates of the two groups of Beracsurf and Curosurf surfactant did not show a significant difference (p=0.962, 0.763, 0.725 and 0.149, respectively). Further, the comparison of the mean number of days requiring respiratory support, days free from respiratory support, and hospitalization days among neonates of the two groups of Beracsurf and Curosurf surfactant injection did not show a significant difference (p=0.910, 0.725, and 0.898, respectively). Additionally, the comparison of the time of initiation of feeding and the time of reaching maximum feeding among neonates of the two groups of Beracsurf and Curosurf surfactant injection also did not show significant differences (p=0.881 and 0.903, respectively). CONCLUSION Based on the fact that Beracsurf and Curosurf surfactants did not show significant differences in the treatment outcomes of RDS in preterm neonates, it is suggested that the Iranianmade surfactant, Beracsurf, should be used for the treatment of these neonates due to its cost-effectiveness and availability compared to Curosurf.
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来源期刊
CiteScore
4.30
自引率
0.00%
发文量
66
期刊介绍: Current Pediatric Reviews publishes frontier reviews on all the latest advances in pediatric medicine. The journal’s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians in pediatric medicine.
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