{"title":"[两例肾病综合征患儿因利妥昔单抗引起的血清病]。","authors":"Y. Yang, H. Bai","doi":"10.3760/cma.j.cn112140-20231019-00304","DOIUrl":null,"url":null,"abstract":"\n 2例原发性肾病综合征患儿使用利妥昔单抗(RTX)诱发血清病,诊断为利妥昔单抗诱导血清病(RISS)。例1,男,8岁,确诊原发性肾病综合征5年余,病理为局灶节段性肾小球硬化,应用第2剂RTX治疗6 d后,出现急性皮疹、关节肿痛、高热及休克等血清病表现,经激素等治疗5 d逐渐好转。例2,女,9岁,确诊原发性单纯型肾病综合征3年2个月,病理诊断微小病变,应用第2剂RTX治疗11 d后,出现急性皮疹、关节肿痛表现,2 d后自行好转。2例儿童肾病综合征RISS均发生在学龄期患儿重复使用RTX时,症状出现在再次应用1~2周内,主要表现为皮疹、关节痛、发热。严重者出现休克。激素为RISS的主要治疗方法,轻者自行缓解。.\n","PeriodicalId":23998,"journal":{"name":"Zhonghua er ke za zhi = Chinese journal of pediatrics","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Two cases of rituximab induced serum sickness in children with nephrotic syndrome].\",\"authors\":\"Y. Yang, H. Bai\",\"doi\":\"10.3760/cma.j.cn112140-20231019-00304\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\\n 2例原发性肾病综合征患儿使用利妥昔单抗(RTX)诱发血清病,诊断为利妥昔单抗诱导血清病(RISS)。例1,男,8岁,确诊原发性肾病综合征5年余,病理为局灶节段性肾小球硬化,应用第2剂RTX治疗6 d后,出现急性皮疹、关节肿痛、高热及休克等血清病表现,经激素等治疗5 d逐渐好转。例2,女,9岁,确诊原发性单纯型肾病综合征3年2个月,病理诊断微小病变,应用第2剂RTX治疗11 d后,出现急性皮疹、关节肿痛表现,2 d后自行好转。2例儿童肾病综合征RISS均发生在学龄期患儿重复使用RTX时,症状出现在再次应用1~2周内,主要表现为皮疹、关节痛、发热。严重者出现休克。激素为RISS的主要治疗方法,轻者自行缓解。.\\n\",\"PeriodicalId\":23998,\"journal\":{\"name\":\"Zhonghua er ke za zhi = Chinese journal of pediatrics\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-04-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Zhonghua er ke za zhi = Chinese journal of pediatrics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3760/cma.j.cn112140-20231019-00304\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zhonghua er ke za zhi = Chinese journal of pediatrics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3760/cma.j.cn112140-20231019-00304","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}