亲脂性对药物临床效果的影响

Q3 Medicine

Russian Journal of Cardiology Pub Date : 2024-04-17 DOI:10.15829/1560-4071-2024-5829

A. Skotnikov, M. Melnik, E. A. Zinina, I. V. Sivertseva

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引用次数: 0

摘要

文章详细分析了用于治疗高血压和动脉粥样硬化性血脂异常的各种药物在脂肪介质中的溶解能力（亲脂性）。作者分析了药物的亲脂性水平与其药代动力学、药物间相互作用、临床效果表现和器官保护之间的联系，以及它们影响合并症患者预后的能力。作者以血管紧张素转换酶抑制剂、钙通道阻滞剂和他汀类药物为例，解释了血浆蛋白结合率和分布容积等药效学参数的实际意义，并让读者了解常规使用这些参数的重要性，以便为患者带来临床益处。

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Contribution of lipophilicity to the clinical effects of drugs

The article is devoted to a detailed analysis of the action of various drugs used in the treatment of hypertension and atherogenic dyslipidemia, depending on their ability to dissolve in fatty media (lipophilicity). The authors analyze connection between the lipophilicity level of drugs and their pharmacokinetics, drug-drug interactions, the manifestations of clinical effects and organ protection, as well as their ability to influence the prognosis of comorbid patients. Using angiotensin-converting enzyme inhibitors, calcium channel blockers, and statins as examples, the authors explain the practical significance of pharmacological parameters such as plasma protein binding and distribution volume, and also develop an understanding of the importance of its routine use in order to obtain clinical benefits for patients.

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来源期刊

Russian Journal of Cardiology Medicine-Cardiology and Cardiovascular Medicine

CiteScore

2.20

自引率

0.00%

发文量

185

审稿时长

1 months

期刊介绍： Russian Journal of Cardiology has been issued since 1996. The language of this publication is Russian, with tables of contents and abstracts of all articles presented in English as well. Editor-in-Chief: Prof. Eugene V.Shlyakhto, President of the Russian Society of Cardiology. The aim of the journal is both scientific and practical, also with referring to organizing matters of the Society. The best of all cardiologic research in Russia is submitted to the Journal. Moreover, it contains useful tips and clinical examples for practicing cardiologists. Journal is peer-reviewed, with multi-stage editing. The editorial board is presented by the leading cardiologists from different cities of Russia.