68Ga-FAPI PET/CT 与 18F-FDG PET/CT 在胃肿瘤原发和转移病灶中的头对头比较：系统综述和荟萃分析。

IF 0.9 4区医学 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Hellenic journal of nuclear medicine Pub Date : 2024-04-18 DOI:10.1967/s002449912703

Cailiang Gao, Huiting Liu, Lirong Zhou, Wei Huang, Xue Liu

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引用次数: 0

摘要

目的我们的研究旨在对镓-68-成纤维细胞活化蛋白抑制剂（68Ga-FAPI）正电子发射断层扫描/计算机断层扫描（PET/CT）和氟-18-氟脱氧葡萄糖（18F-FDG）正电子发射断层扫描/计算机断层扫描（PET/CT）在胃肿瘤原发和转移病灶中的应用进行头对头比较，以确定更优越的诊断工具。材料与方法截至 2023 年 3 月 31 日，利用特定数据的布尔逻辑策略在 PubMed、Embase 和 Cochrane Library 数据库中进行了系统检索。对 68Ga-FAPI 和 18F-FDG PET/CT 在胃癌病变中的敏感性（SEN）和特异性（SPE）进行了评估。结果分析涉及 5 项研究中的 141 名胃癌患者和 2753 个转移病灶，总体研究质量令人满意，无明显发表偏倚。患者层面的数据显示，68Ga-FAPI 的综合 SEN 为 0.95（95% CI：0.90-0.98），18F-FDG 为 0.84（95% CI：0.77-0.89）。在病灶水平，68Ga-FAPI 的综合 SEN 为 0.91（95% CI：0.84-0.96），18F-FDG 为 0.72（95% CI：0.63-0.80）。68Ga-FAPI和18F-FDG检测淋巴结转移的汇总SEN分别为0.78（95% CI：0.74-0.82）和0.35（95% CI：0.30-0.39），汇总SPE值分别为0.99（95% CI：0.98-0.99）和0.97（95% CI：0.96-0.98）。在检测远处转移方面，68Ga-FAPI和18F-FDG的集合SEN值分别为0.97（95% CI：0.96-0.98）和0.69（95% CI：0.66-0.72），集合SPE值分别为0.86（95% CI：0.82-0.89）和0.64（95% CI：0.59-0.68）。结论该荟萃分析认为，在评估原发性胃肿瘤、淋巴结和远处转移方面，68Ga-FAPI PET/CT 的敏感性明显高于 18F-FDG PET/CT，但淋巴结转移的特异性差异不显著。

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Head to head comparison of 68Ga-FAPI PET/CT with 18F-FDG PET/CT in primary and metastatic lesions of gastric tumor: A systematic review and meta-analysis.

OBJECTIVE Our study aims to head to head compare the application of gallium-68-fibroblast activation proteininhibitor (68Ga-FAPI) positron emission tomography/computed tomography (PET/CT) and fluorine-18-fluorodeoxyglucose (18F-FDG) PET/CT in primary and metastatic lesions of gastric tumor to determine the superior diagnostic tool. MATERIALS AND METHODS A systematic search, up to March 31, 2023, across PubMed, Embase, and Cochrane Library databases utilized a data-specific Boolean logic strategy. Sensitivity (SEN) and specificity (SPE) evaluations of 68Ga-FAPI and 18F-FDG PET/CT in gastric cancer lesions were conducted. The quality of the studies was assessed using QUADAS-2, and publication bias was examined through Begg and Egger tests. RESULTS Analysis involved 141 gastric tumor patients and 2753 metastatic lesions in five studies, with overall satisfactory study quality and no apparent publication bias. Patient-level data showed a combined SEN of 0.95 (95% CI: 0.90-0.98) for 68Ga-FAPI and 0.84 (95% CI: 0.77-0.89) for 18F-FDG. At the lesion level, combined SENs were 0.91 (95% CI: 0.84-0.96) for 68Ga-FAPI and 0.72 (95% CI: 0.63-0.80) for 18F-FDG. The pooled SEN for detecting lymph node metastases was 0.78 (95% CI: 0.74-0.82) for 68Ga-FAPI and 0.35 (95% CI: 0.30-0.39) for 18F-FDG, with pooled SPE values of 0.99 (95% CI: 0.98-0.99) and 0.97 (95% CI: 0.96-0.98), respectively. For detecting distant metastases, pooled SEN values were 0.97 (95% CI: 0.96-0.98) and 0.69 (95% CI: 0.66-0.72) for 68Ga-FAPI and 18F-FDG, with pooled SPE values of 0.86 (95% CI: 0.82-0.89) and 0.64 (95% CI: 0.59-0.68), respectively. CONCLUSION This meta-analysis concluded that 68Ga-FAPI PET/CT was significantly more sensitive than 18F-FDG PET/CT in assessing primary gastric tumors, lymph nodes, and distant metastases, but the difference in the specificity of lymph node metastasis was not significant.

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来源期刊

Hellenic journal of nuclear medicine 医学-核医学

CiteScore

1.40

自引率

6.70%

发文量

审稿时长

>12 weeks

期刊介绍： The Hellenic Journal of Nuclear Medicine published by the Hellenic Society of Nuclear Medicine in Thessaloniki, aims to contribute to research, to education and cover the scientific and professional interests of physicians, in the field of nuclear medicine and in medicine in general. The journal may publish papers of nuclear medicine and also papers that refer to related subjects as dosimetry, computer science, targeting of gene expression, radioimmunoassay, radiation protection, biology, cell trafficking, related historical brief reviews and other related subjects. Original papers are preferred. The journal may after special agreement publish supplements covering important subjects, dully reviewed and subscripted separately.