用于修复脊髓损伤的电活性生物支架的进展。

IF 3.9 3区医学 Q2 ENGINEERING, BIOMEDICAL

Biomedical materials Pub Date : 2024-04-18 DOI:10.1088/1748-605X/ad4079

Zeqi Liu, Jiahui Lai, Dexin Kong, Yannan Zhao, Jiakang Zhao, Jianwu Dai, Mingming Zhang

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引用次数: 0

摘要

脊髓损伤（SCI）是一种破坏性神经系统疾病，会导致运动或躯体感觉功能丧失，是最具挑战性的世界性医学难题。重建完整的神经回路是脊髓再生的基础。考虑到电信号在神经系统中的关键作用，人们广泛开发了用于脊髓损伤修复的电活性生物支架。它们可以在病变部位产生类似于自然脊髓的导电通路和有利于再生的微环境，从而促进神经元再生和轴突生长，并在功能上重新激活受损的神经回路。在这篇综述中，我们首先展示了损伤性脊髓炎诱发的病理生理特征。然后，介绍电信号在 SCI 修复中的关键作用。在对这些特征进行全面分析的基础上，总结了用于 SCI 修复的电活性生物支架的最新进展，重点介绍了独立使用或与外部电子刺激结合使用的导电生物支架和压电生物支架。最后，总结了生物支架在 SCI 修复中的未来可能面临的挑战和机遇。

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Advances in electroactive bioscaffolds for repairing spinal cord injury.

Spinal cord injury (SCI) is a devastating neurological disorder, leading to loss of motor or somatosensory function, which is the most challenging worldwide medical problem. Re-establishment of intact neural circuits is the basis of spinal cord regeneration. Considering the crucial role of electrical signals in the nervous system, electroactive bioscaffolds have been widely developed for SCI repair. They can produce conductive pathways and a pro-regenerative microenvironment at the lesion site similar to that of the natural spinal cord, leading to neuronal regeneration and axonal growth, and functionally reactivating the damaged neural circuits. In this review, we first demonstrate the pathophysiological characteristics induced by SCI. Then, the crucial role of electrical signals in SCI repair is introduced. Based on a comprehensive analysis of these characteristics, recent advances in the electroactive bioscaffolds for SCI repair are summarized, focusing on both the conductive bioscaffolds and piezoelectric bioscaffolds, used independently or in combination with external electronic stimulation. Finally, thoughts on challenges and opportunities that may shape the future of bioscaffolds in SCI repair are concluded.

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来源期刊

Biomedical materials 工程技术-材料科学：生物材料

CiteScore

6.70

自引率

7.50%

发文量

294

审稿时长

3 months

期刊介绍： The goal of the journal is to publish original research findings and critical reviews that contribute to our knowledge about the composition, properties, and performance of materials for all applications relevant to human healthcare. Typical areas of interest include (but are not limited to): -Synthesis/characterization of biomedical materials- Nature-inspired synthesis/biomineralization of biomedical materials- In vitro/in vivo performance of biomedical materials- Biofabrication technologies/applications: 3D bioprinting, bioink development, bioassembly & biopatterning- Microfluidic systems (including disease models): fabrication, testing & translational applications- Tissue engineering/regenerative medicine- Interaction of molecules/cells with materials- Effects of biomaterials on stem cell behaviour- Growth factors/genes/cells incorporated into biomedical materials- Biophysical cues/biocompatibility pathways in biomedical materials performance- Clinical applications of biomedical materials for cell therapies in disease (cancer etc)- Nanomedicine, nanotoxicology and nanopathology- Pharmacokinetic considerations in drug delivery systems- Risks of contrast media in imaging systems- Biosafety aspects of gene delivery agents- Preclinical and clinical performance of implantable biomedical materials- Translational and regulatory matters