探索香烟烟雾提取物对维生素 B12 的影响：通过体外评估了解甲基钴胺素和羟基钴胺素向氰钴胺的转化情况

IF 3.4 Q2 BIOCHEMICAL RESEARCH METHODS

Biochemistry Research International Pub Date : 2024-04-18 DOI:10.1155/2024/8827402

M. A. Al Zoubi, Mus’aab A. Al-Oun, Fatima Yacoub Abusahyoun, Manal Abualarja, Asmaa Al Smadi, Bahaa Al-Trad, Sura A. Awadin, K. Al-Batayneh, Mai Elaarag, R. Al‐Zoubi

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引用次数: 0

摘要

维生素 B12（钴胺素）是一种水溶性分子，新陈代谢、血液和 DNA 合成以及神经系统发育的正常运作都需要它。维生素 B12 有几种形式：甲基钴胺素（MeCbl）、腺苷钴胺素（AdoCbl）、羟基钴胺素（OHCbl）和氰基钴胺素（CNCbl）。本研究旨在评估香烟烟雾对维生素 B12 的甲基钴胺素和羟基钴胺素化学结构的影响。接触香烟烟雾后，甲基钴胺素（MeCbl）和羟基钴胺素（OHCbl）受到明显影响。MeCbl 和 OHCbl 与 CNCbl 之间的 Rt 相似，表明暴露于香烟烟雾提取物会使 MeCbl 和 OHCbl 化学变化为 CNCbl，值得进行体内研究调查。

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Exploring the Impact of Cigarette Smoke Extracts on Vitamin B12: Insights into the Transformation of Methylcobalamin and Hydroxycobalamin to Cyanocobalamin through In Vitro Evaluation

Vitamin B12 (cobalamin) is a water-soluble molecule required for the proper functioning of metabolism, blood and DNA synthesis, and neurological development. Vitamin B12 exists in several forms: methylcobalamin (MeCbl), adenosylcobalamin (AdoCbl), hydroxycobalamin (OHCbl), and cyanocobalamin (CNCbl). This study aimed to evaluate the effect of cigarette smoke on the chemical structure of methylcobalamin and hydroxycobalamin forms of vitamin B12. MeCbl and OHCbl were markedly affected by exposure to cigarette smoke. The resemblance of the Rt between MeCbl and OHCbl and CNCbl indicates that exposure to cigarette smoke extracts chemically alters MeCbl and OHCbl to CNCbl, warranting in vivo research investigations.

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来源期刊

Biochemistry Research International BIOCHEMICAL RESEARCH METHODS-

CiteScore

6.30

自引率

0.00%

发文量

审稿时长

14 weeks